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Comment
. 2020 Sep 1;75(9):2704-2706.
doi: 10.1093/jac/dkaa190.

Lopinavir/ritonavir in COVID-19 patients: maybe yes, but at what dose?

Sara Baldelli  1 , Mario Corbellino  2 , Emilio Clementi  3   4 , Dario Cattaneo  1   5 , Cristina Gervasoni  2   5
Affiliations
Comment

Lopinavir/ritonavir in COVID-19 patients: maybe yes, but at what dose?

Sara Baldelli et al. J Antimicrob Chemother. .
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Box plot (showing 5th, 25th, 50th, 75th and 95th percentiles) of lopinavir (left side) and ritonavir (right side) trough concentrations measured in COVID-19 versus HIV-infected patients. Dashed lines represent the therapeutic window of lopinavir concentrations described in HIV-infected patients. *P < 0.0001 versus HIV-infected patients.
See this image and copyright information in PMC

Comment on

  • A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19.
    Cao B, Wang Y, Wen D, Liu W, Wang J, Fan G, Ruan L, Song B, Cai Y, Wei M, Li X, Xia J, Chen N, Xiang J, Yu T, Bai T, Xie X, Zhang L, Li C, Yuan Y, Chen H, Li H, Huang H, Tu S, Gong F, Liu Y, Wei Y, Dong C, Zhou F, Gu X, Xu J, Liu Z, Zhang Y, Li H, Shang L, Wang K, Li K, Zhou X, Dong X, Qu Z, Lu S, Hu X, Ruan S, Luo S, Wu J, Peng L, Cheng F, Pan L, Zou J, Jia C, Wang J, Liu X, Wang S, Wu X, Ge Q, He J, Zhan H, Qiu F, Guo L, Huang C, Jaki T, Hayden FG, Horby PW, Zhang D, Wang C. Cao B, et al. N Engl J Med. 2020 May 7;382(19):1787-1799. doi: 10.1056/NEJMoa2001282. Epub 2020 Mar 18. N Engl J Med. 2020. PMID: 32187464 Free PMC article. Clinical Trial.

References

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