Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2020 Jul;7(7):1240-1244.
doi: 10.1002/acn3.51071. Epub 2020 Jun 10.

De Novo Status Epilepticus in patients with COVID-19

Sana Somani  1 , Sandipan Pati  1 , Tyler Gaston  1 , Alissa Chitlangia  1 , Shruti Agnihotri  1
Affiliations
Case Reports

De Novo Status Epilepticus in patients with COVID-19

Sana Somani et al. Ann Clin Transl Neurol. 2020 Jul.

Abstract

Neurological complications are increasingly recognized with SARS-CoV-2, the causative pathogen for COVID-19. We present a single-center retrospective case series reporting the EEG and outcome of de novo status epilepticus (SE) in two African-American women with laboratory-confirmed SARS-CoV-2 virus. SE was the initial presentation in one asymptomatic individual. Patient 2 had COVID-19 pneumonia, and fluctuating mental status that raised the suspicion of subclinical SE. The patient with older age and higher comorbidities failed to recover from the viral illness that has no definitive treatment.

PubMed Disclaimer

Conflict of interest statement

None.

Figures

Figure 1
Figure 1
Scalp EEG in a bipolar montage from subject #1 demonstrating emergence of low amplitude ictal fast rhythmic activity over left fronto‐central and midline regions (marked with an arrow). Timebase 15 mm/sec, sensitivity 5 uV/mm, LFF 1 Hz, HFF 70 Hz.
Figure 2
Figure 2
Scalp EEG in a bipolar montage from subject #1 demonstrating the progression of the seizure (Fig. 1) and clinical accompaniment with bilateral tonic–clonic activity. Timebase 15 mm/sec, sensitivity 5 uV/mm, LFF 1 Hz, HFF 70 Hz.
Figure 3
Figure 3
Scalp EEG in a bipolar montage from subject #2 demonstrating independent periodic discharges over left (marked with double asterisks) and the right hemisphere (marked with an asterisk) and a focal seizure emanating from the right fronto‐central‐parietal region (marked with an arrow).Timebase 30mm/sec, sensitivity 5 uV/mm, LFF 1 Hz, HFF 70 Hz.
Figure 4
Figure 4
Scalp EEG in a bipolar montage from subject #2 demonstrating a focal seizure emanating from the left fronto‐central‐parietal region (marked with an arrow). Timebase 30mm/sec, sensitivity 5 uV/mm, LFF 1 Hz, HFF 70 Hz.
See this image and copyright information in PMC

References

    1. Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID‐19 in Wuhan, China: a retrospective cohort study. Lancet 2020;395(10229):1054–1062. - PMC - PubMed
    1. Wu C, Chen X, Cai Y, et al. Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China. JAMA Internal Medicine 2020. 10.1001/jamainternmed.2020.0994 - DOI - PMC - PubMed
    1. Mao L, Wang M, Chen S, et al. Neurological Manifestations of Hospitalized Patients with COVID‐19 in Wuhan, China: a retrospective case series study. medRxiv 2020.
    1. Thebault R. Ba Tran AWV. The coronavirus is infecting and killing black Americans at an alarmingly high rate. 2020. https://www.washingtonpost.com/
    1. Gofton TE, Gaspard N, Hocker SE, et al. New onset refractory status epilepticus research. Neurology 2019;92(17):802–810. - PubMed

Publication types

LinkOut - more resources