Review
doi: 10.1016/j.pt.2020.03.003.
Epub 2020 Apr 6.
A More Granular View of Neutrophils in Malaria
Affiliations
- PMID: 32407680
- DOI: 10.1016/j.pt.2020.03.003
Item in Clipboard
Review
A More Granular View of Neutrophils in Malaria
Trends Parasitol.
2020 Jun.
Free article
Abstract
Neutrophils are abundant innate immune cells with crucial roles in immunity and vascular inflammation. Recent evidence indicates that neutrophils have a dual role in malaria, contributing to both pathogenesis and control of Plasmodium. We discuss emerging mechanisms behind these opposing functions and identify key outstanding questions.
Keywords: innate immunity; malaria; neutrophils.
Copyright © 2020 Elsevier Ltd. All rights reserved.
Similar articles
-
Neutrophils and Malaria.Front Immunol. 2018 Dec 19;9:3005. doi: 10.3389/fimmu.2018.03005. eCollection 2018. Front Immunol. 2018. PMID: 30619354 Free PMC article. Review.
-
Unravelling the roles of innate lymphoid cells in cerebral malaria pathogenesis.Parasite Immunol. 2018 Feb;40(2). doi: 10.1111/pim.12502. Parasite Immunol. 2018. PMID: 29117626 Review.
-
Parasite Recognition and Signaling Mechanisms in Innate Immune Responses to Malaria.Front Immunol. 2018 Dec 19;9:3006. doi: 10.3389/fimmu.2018.03006. eCollection 2018. Front Immunol. 2018. PMID: 30619355 Free PMC article. Review.
-
Neutrophil extracellular traps drive inflammatory pathogenesis in malaria.Sci Immunol. 2019 Oct 18;4(40):eaaw0336. doi: 10.1126/sciimmunol.aaw0336. Sci Immunol. 2019. PMID: 31628160 Free PMC article.
-
Innate immunity to malaria-The role of monocytes.Immunol Rev. 2020 Jan;293(1):8-24. doi: 10.1111/imr.12830. Epub 2019 Dec 16. Immunol Rev. 2020. PMID: 31840836 Free PMC article. Review.
Cited by
-
Multicohort transcriptome analysis of whole blood identifies robust human response signatures in Plasmodium falciparum infections.Malar J. 2022 Nov 15;21(1):333. doi: 10.1186/s12936-022-04374-5. Malar J. 2022. PMID: 36380373 Free PMC article.
-
The impact of Plasmodium-driven immunoregulatory networks on immunity to malaria.Nat Rev Immunol. 2024 Sep;24(9):637-653. doi: 10.1038/s41577-024-01041-5. Epub 2024 Jun 11. Nat Rev Immunol. 2024. PMID: 38862638 Free PMC article. Review.
-
Pathogenetic mechanisms and treatment targets in cerebral malaria.Nat Rev Neurol. 2023 Nov;19(11):688-709. doi: 10.1038/s41582-023-00881-4. Epub 2023 Oct 19. Nat Rev Neurol. 2023. PMID: 37857843 Review.
-
Neutrophils dominate in opsonic phagocytosis of P. falciparum blood-stage merozoites and protect against febrile malaria.Commun Biol. 2021 Aug 19;4(1):984. doi: 10.1038/s42003-021-02511-5. Commun Biol. 2021. PMID: 34413459 Free PMC article.
-
Myeloperoxidase and Other Markers of Neutrophil Activation Associate With Malaria and Malaria/HIV Coinfection in the Human Placenta.Front Immunol. 2021 Oct 19;12:682668. doi: 10.3389/fimmu.2021.682668. eCollection 2021. Front Immunol. 2021. PMID: 34737733 Free PMC article. Clinical Trial.
