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. 2020 May 13;27(5):695-698.
doi: 10.1016/j.chom.2020.04.022.

Rational Vaccine Design in the Time of COVID-19

Dennis R Burton  1 , Laura M Walker  2
Affiliations

Rational Vaccine Design in the Time of COVID-19

Dennis R Burton et al. Cell Host Microbe. .

Abstract

As scientists consider SARS-CoV-2 vaccine design, we discuss problems that may be encountered and how to tackle them by what we term "rational vaccine design." We further discuss approaches to pan-coronavirus vaccines. We draw on experiences from recent research on several viruses including HIV and influenza, as well as coronaviruses.

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Figures

Figure 1
Figure 1
Graphical Visualization of Antibodies Binding to Coronavirus Spike Proteins on the Virion Surface (A) Coronavirus particle studded with S glycoprotein molecules (red) and antibody IgG molecules (purple), bound and free. The E and M proteins are not shown in this representation. (B) Two S glycoprotein molecules on the virus surface, one with one IgG molecule (purple) bound, one with two IgG molecules bound. Only the first two glycan residues of each glycan chain are shown.
See this image and copyright information in PMC

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