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. 2020 May 13;27(5):699-703.
doi: 10.1016/j.chom.2020.04.021.

The Challenges of Vaccine Development against a New Virus during a Pandemic

Michael S Diamond  1 , Theodore C Pierson  2
Affiliations

The Challenges of Vaccine Development against a New Virus during a Pandemic

Michael S Diamond et al. Cell Host Microbe. .

Abstract

The rapid emergence of a highly pathogenic, readily transmissible coronavirus has resulted in a global pandemic, affecting millions and destabilizing economies. This catastrophe triggered a clarion call for the immediate deployment of a protective vaccine. We describe the unique challenges of developing a vaccine against SARS-CoV-2 in a pandemic setting.

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Conflict of interest statement

Declaration of Interests M.S.D. is a consultant for Inbios, Vir Biotechnology, and NGM Biopharmaceuticals, and is on the Scientific Advisory Board of Moderna. The Diamond laboratory at Washington University School of Medicine has received sponsored research agreements from Moderna.

Figures

Figure 1
Figure 1
Structure of the SARS-CoV-2 (A) The SARS-CoV-2 is a spherical virus particle that incorporates three structural proteins into its lipid envelope (S, M, and E) and encapsidates a positive-stranded RNA genome in complex with the N protein. (B) The structure of the S protein trimer was solved using cryo-electron microscopy and is shown (PDB: 6VYB) (Wrapp et al., 2020). The RBD (shown in green) may existing in an open or closed (up or down) structural state; the RBD of one of the three S protomers within the trimer is shown in the up position.
See this image and copyright information in PMC

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