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. 2020 Sep:142:109824.
doi: 10.1016/j.mehy.2020.109824. Epub 2020 May 7.

What about the original antigenic sin of the humans versus SARS-CoV-2?

Luca Roncati  1 , Beniamino Palmieri  2
Affiliations

What about the original antigenic sin of the humans versus SARS-CoV-2?

Luca Roncati et al. Med Hypotheses. 2020 Sep.
No abstract available

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
In an ideal immune system (on the left) to SARS-CoV-2 and its antigenic variants corresponds always a specific adaptive immunity, as shown by the color matching (red-red, blue-blue, green-green) between a symbolic antibody and the spike proteins, which surround the outer surface of the virion conferring to it the characteristic corona aspect on electron microscopy; in an OAS model (on the right), the specific adaptive immune response (red antibody) is only mounted against the original virus (red colored) and it is also used to fight the mutated versions (blue colored and green colored) of the virus, resulting in a maladaptive response less specific and less effective [the 3D illustration of SARS-CoV-2 with the spike proteins in red has been created by Alissa Eckert, MS, and Dan Higgins, MAM, at the Centers for Disease Control and Prevention (CDC) of Atlanta, Georgia, USA, placed in the public domain and thus free of any copyright restrictions].
See this image and copyright information in PMC

References

    1. Francis T. On the doctrine of original antigenic sin. Proc Am Philos Soc. 1960;104(6):572–578.
    1. Viboud C., Epstein S.L. First flu is forever. Science. 2016;354(6313):706–707. - PubMed
    1. Hoskins T.W., Davies J.R., Allchin A., Miller C.L. Controlled trial of inactivated influenza vaccine containing the a-Hong Kong strain during an outbreak of influenza due to the a-England-42-72 strain. Lancet. 1973;2(7821):116–120. - PubMed
    1. Mongkolsapaya J., Dejnirattisai W., Xu X.N., Tangthawornchaikul N. Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever. Nat Med. 2003;9(7):921–927. - PubMed
    1. Klenerman P., Zinkernagel R.M. Original antigenic sin impairs cytotoxic T lymphocyte responses to viruses bearing variant epitopes. Nature. 1998;394(6692):482–485. - PubMed

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