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Review
. 2020 May 12;12(5):533.
doi: 10.3390/v12050533.

Cell Culture Systems and Drug Targets for Hepatitis A Virus Infection

Tatsuo Kanda  1 , Reina Sasaki  1 , Ryota Masuzaki  1 , Naoki Matsumoto  1 , Masahiro Ogawa  1 , Mitsuhiko Moriyama  1
Affiliations
Review

Cell Culture Systems and Drug Targets for Hepatitis A Virus Infection

Tatsuo Kanda et al. Viruses. .

Abstract

Hepatitis A virus (HAV) infection is one of the major causes of acute hepatitis, and this infection occasionally causes acute liver failure. HAV infection is associated with HAV-contaminated food and water as well as sexual transmission among men who have sex with men. Although an HAV vaccine has been developed, outbreaks of hepatitis A and life-threatening severe HAV infections are still observed worldwide. Therefore, an improved HAV vaccine and anti-HAV drugs for severe hepatitis A should be developed. Here, we reviewed cell culture systems for HAV infection, and other issues. This review may help with improving the HAV vaccine and developing anti-HAV drugs.

Keywords: 5′ UTR; Anti-HAV; HAV; Huh7; IRES; PLC/PRF/5; drug screening; subgenomic replicon; vaccine.

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Conflict of interest statement

The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

Figures

Figure 1
Figure 1
Life cycle of the hepatitis A virus and candidates of anti-HAV drug targets (open squares). HAVcr-1, hepatitis A virus cellular receptor 1; IRES, internal ribosomal entry site; HAV, naked HAV; eHAV, quasi-enveloped HAV; bold black circle, envelope; yellow pentagon, viral capsid [10,13,71,72,73,74,75,76,77,78,79,80,81,82].
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