Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Jul:112:110813.
doi: 10.1016/j.msec.2020.110813. Epub 2020 Mar 6.

Biodegradable poly(l-lactide)/calcium phosphate composites with improved properties for orthopedics: Effect of filler and polymer crystallinity

Varvara A Demina  1 , Sergei V Krasheninnikov  2 , Alexander I Buzin  3 , Roman A Kamyshinsky  4 , Natalya V Sadovskaya  5 , Evgeny N Goncharov  6 , Natalya A Zhukova  7 , Mikhail V Khvostov  8 , Alla V Pavlova  7 , Tatjana G Tolstikova  8 , Nikita G Sedush  3 , Sergei N Chvalun  3
Affiliations

Biodegradable poly(l-lactide)/calcium phosphate composites with improved properties for orthopedics: Effect of filler and polymer crystallinity

Varvara A Demina et al. Mater Sci Eng C Mater Biol Appl. 2020 Jul.

Abstract

Biodegradable poly(l-lactide)/calcium phosphate composites are promising materials for fabrication of bone fixation implants with improved properties. Multistage compounding was proposed as an efficient method for the preparation of biodegradable poly(l-lactide)/calcium phosphate composites with submicron filler dispersion and mechanical characteristics similar to native bone. The improvement of the characteristics is caused both by the filler itself and by the increase of polymer crystallinity due to the nucleation effect. The technique allows to fabricate biodegradable composites with controlled properties by varying concentration and type of the filler as well as degree of PLLA matrix crystallinity. Animal studies revealed that all the composites were biocompatible and non-toxic.

Keywords: Biodegradable polymers; Bone tissue engineering; Hydroxyapatite; Polylactide; Polymer composites.

PubMed Disclaimer

Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

LinkOut - more resources