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. 2020 Jul:112:110863.
doi: 10.1016/j.msec.2020.110863. Epub 2020 Mar 19.

Biocompatible alginate silica supported silver nanoparticles composite films for wound dressing with antibiofilm activity

Valeria Ambrogi  1 , Donatella Pietrella  2 , Anna Donnadio  3 , Loredana Latterini  4 , Alessandro Di Michele  5 , Ilaria Luffarelli  3 , Maurizio Ricci  3
Affiliations

Biocompatible alginate silica supported silver nanoparticles composite films for wound dressing with antibiofilm activity

Valeria Ambrogi et al. Mater Sci Eng C Mater Biol Appl. 2020 Jul.

Abstract

Alginate films containing pyrogenic silica supported silver nanoparticles were prepared as potential wound dressings. First silica supported silver nanoparticles (CAB-O-SIL-Ag) were prepared via solid state sintering route without the use of any solvent and reducing agent. The obtained composite was characterized by X-ray powder diffraction, transmission electron microscopy and UV-vis spectroscopy which evidenced the presence of 8-20 nm spherical silver nanoparticles uniformly distributed and grown on the silica surface. Then the CAB-O-SIL-Ag was used as filler to prepare alginate films by casting method and successive gelation. Films with two different silver concentrations were prepared. They showed good hydration properties and a very slow silver release. Films exhibited antimicrobial and antibiofilm activities against Staphylococcus aureus and Pseudomonas aeruginosa and showed no cytotoxicity towards human skin keratinocytes and human fibroblasts HuDe.

Keywords: Alginate films; Antibiofilm activity; Cytotoxicity; Silica supported silver nanoparticles; Wound dressings.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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