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Case Reports
. 2020 Jun 15;192(24):E647-E650.
doi: 10.1503/cmaj.200821. Epub 2020 May 14.

Probable congenital SARS-CoV-2 infection in a neonate born to a woman with active SARS-CoV-2 infection

Maksim Kirtsman  1 , Yenge Diambomba  1 , Susan M Poutanen  1 , Ann K Malinowski  1 , Evangelia Vlachodimitropoulou  1 , W Tony Parks  1 , Laura Erdman  1 , Shaun K Morris  1 , Prakesh S Shah  2
Affiliations
Case Reports

Probable congenital SARS-CoV-2 infection in a neonate born to a woman with active SARS-CoV-2 infection

Maksim Kirtsman et al. CMAJ. .
No abstract available

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Conflict of interest statement

Competing interests: Susan Poutanen reports honoraria from Merck related to advisory boards and talks, honoraria from Verity, Cipher Pharmaceuticals and Paladin Labs related to advisory boards, partial conference travel reimbursement from COPAN Diagnostics, and research support from Accelerate Diagnostics and bioMérieux, all outside the submitted work. Ann Malinowski is a member of the Alexion post-pregnancy thrombotic microangiopathy advisory board and participated in a speaking engagement commisioned by Alexion on thrombotic microangiopathy in pregnancy. No other competing interests were declared.

Figures

Figure 1:
Figure 1:
Placental photomicrographs. A) On low-power imaging, broad zones of cellular infiltrates are noted frequently but randomly throughout the section (arrows). The most normal area is present on the right side of the slide (hematoxylin–eosin, original magnification ×2). B) Higher-power view shows infiltration of the intervillous space by chronic inflammatory cells (arrows). The chorionic villi are largely spared from the infiltration but, instead, show extensive early necrosis of the syncytiotrophoblast layer. Early perivillous fibrin deposition is also present (hematoxylin–eosin, original magnification ×20). C) High-power view highlights the early infarction, with extensive smudginess and early fragmentation of the syncytiotrophoblast nuclei (arrows) (hematoxylin–eosin, original magnification ×40). D) Immunostaining for the macrophage marker CD68 shows large numbers of the chronic inflammatory cells in the intervillous space, frequently encircling the chorionic villi (CD68 immunostain, original magnification ×20).
See this image and copyright information in PMC

Comment in

References

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