Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 May;25(5):1203-1211.
doi: 10.1007/s11605-020-04636-0. Epub 2020 May 14.

Does Chemotherapy-Induced Liver Injury Impair Postoperative Outcomes After Laparoscopic Liver Resection for Colorectal Metastases?

Maud Neuberg  1 , Ioannis Triantafyllidis  1   2 , Marine Lefevre  3 , Mostefa Bennamoun  4 , Anthony Sarran  5 , Marc Beaussier  1 , Christophe Louvet  4 , Brice Gayet  1 , David Fuks  6
Affiliations
Free article

Does Chemotherapy-Induced Liver Injury Impair Postoperative Outcomes After Laparoscopic Liver Resection for Colorectal Metastases?

Maud Neuberg et al. J Gastrointest Surg. 2021 May.
Free article

Abstract

Background: Chemotherapy-associated liver injuries (CALI) have been associated with poor postoperative outcome after open liver resection. To date, no data concerning any correlation of CALI and laparoscopic liver resection (LLR) are available. In the present study, we evaluated the impact of CALI on short-term outcomes in patients undergoing LLR.

Materials and methods: All patients who underwent in our department LLR for colorectal liver metastases (CRLM) from 2000 to 2016 were retrospectively reviewed. Patients were divided in 4 groups according to their pathological histology. In group 1 patients had normal liver parenchyma. Group 2 included patients with steatosis and steatohepatitis. Patients with sinusoidal obstruction syndrome (SOS) and nodular regenerative hyperplasia (NRH) were allocated to group 3, whereas the remaining with fibrosis and cirrhosis, were assigned to group 4.

Results: A total of 490 LLR for CRLM were included in the study. Perioperative details and morbidity did not differ significantly between the four groups. Subgroup analysis showed that NRH was associated with higher amount of blood loss (p = 0.043), overall (p = 0.021) and liver-specific morbidity (p = 0.039).

Conclusion: NRH is a severe form of CALI that may worsen the short-term outcomes of patients undergoing LLR for CRLM. However, the remaining forms of CALI do not have a significant impact on perioperative outcomes after LLR.

Keywords: CALI; Chemotherapy; Colorectal liver metastases; Laparoscopic liver resection; Postoperative outcomes.

PubMed Disclaimer

References

    1. Jones RP, Kokudo N, Folprecht G, et al. Colorectal liver metastases: a critical review of state of the art. Liver Cancer 2017;6(1):66–71. - DOI
    1. McMillan DC, McArdle CS. Epidemiology of colorectal liver metastases. Surg Oncol. 2007;16(1):3–5. - PubMed - DOI - PMC
    1. Beamish P, Lemke M, Li J, et al. Validation of clinical risk score for colorectal liver metastases resected in a contemporary multicenter cohort. HPB (Oxford). 2017; 19(8):675-681. - PubMed - DOI - PMC
    1. Adam R, Delvart V, Pascal G, et al. Rescue surgery for unresectable colorectal liver metastases downstaged by chemotherapy : a model to predict long-term survivam. Ann Surg 2004;240:644-657. - PubMed - PMC - DOI
    1. Allen PJ, Kemeny N, Jarnagin W, et al. Importance of response to neoadjuvant chemotherapy in patients undergoing resection of synchronous colorectal liver metastases. J Gastrointest Surg 2003;7:109-115. - PubMed - DOI - PMC

Substances