Multicenter Study

. 2020 Aug;64(4):537-545.

doi: 10.1111/1754-9485.13038. Epub 2020 May 14.

Predictors of patient preference for either whole body magnetic resonance imaging (WB-MRI) or CT/ PET-CT for staging colorectal or lung cancer

Collaborators, Affiliations

Collaborators

STREAMLINE investigators:
A Aboagye, L Agoramoorthy, S Ahmed, A Amadi, G Anand, G Atkin, A Austria, S Ball, F Bazari, R Beable, H Beedham, T Beeston, N Bharwani, G Bhatnagar, A Bhowmik, L Blakeway, D Blunt, P Boavida, D Boisfer, D Breen, S Burke, R Butawan, Y Campbell, E Chang, D Chao, S Chukundah, B Collins, C Collins, V Conteh, J Couture, J Crosbie, H Curtis, A Daniel, L Davis, K Desai, M Duggan, S Ellis, C Elton, A Engledow, C Everitt, S Ferdous, A Frow, M Furneaux, N Gibbons, R Glynne-Jones, A Gogbashian, S Gourtsoyianni, A Green, Laura Green, Liz Green, A Groves, A Guthrie, E Hadley, A Hameeduddin, G Hanid, S Hans, B Hans, A Higginson, L Honeyfield, H Hughes, J Hughes, L Hurl, E Isaac, M Jackson, A Jalloh, R Jannapureddy, A Jayme, A Johnson, E Johnson, P Julka, J Kalasthry, E Karapanagiotou, S Karp, C Kay, J Kellaway, S Khan, D Koh, T Light, P Limbu, S Lock, I Locke, T Loke, A Lowe, N Lucas, S Maheswaran, S Mallett, E Marwood, J McGowan, F Mckirdy, T Mills-Baldock, T Moon, V Morgan, S Nasseri, P Nichols, C Norman, E Ntala, A Nunes, A Obichere, J O'Donohue, I Olaleye, A Onajobi, T O'Shaughnessy, A Padhani, H Pardoe, W Partridge, U Patel, K Perry, W Piga, D Prezzi, K Prior, S Punwani, J Pyers, H Rafiee, F Rahman, I Rajanpandian, S Ramesh, S Raouf, K Reczko, A Reinhardt, D Robinson, P Russell, K Sargus, E Scurr, K Shahabuddin, A Sharp, B Shepherd, K Shiu, H Sidhu, I Simcock, C Simeon, A Smith, D Smith, D Snell, J Spence, R Srirajaskanthan, V Stachini, S Stegner, J Stirling, N Strickland, K Tarver, J Teague, M Thaha, M Train, S Tulmuntaha, N Tunariu, K van Ree, A Verjee, C Wanstall, S Weir, S Wijeyekoon, J Wilson, S Wilson, T Win, L Woodrow, D Yu

Affiliations

¹ Department of Psychological Sciences, Birkbeck, University of London, London, UK.
² Centre for Medical Imaging, University College London, Charles Bell House, UK.
³ Cancer Research UK, University College London Clinical Trials Centre, London, UK.
⁴ UCL Cancer Institute, Paul O Gorman Building, London, UK.
⁵ Cancer Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, Strand, London, UK.
⁶ Lungs for Living Research Centre, UCL Respiratory, Division of Medicine, University College London, London, UK.
⁷ Department of Thoracic Medicine, UCLH and Lungs for Living Research Centre, UCL Respiratory, University College London, London, UK.
⁸ Cancer patient representatives, c/o National Cancer Research Institute, London, UK.
⁹ Research Department of Applied Health Research, University College London, London, UK.
¹⁰ Department of Surgery and Cancer, Imperial College London, Kensington, London, UK.

PMID: 32410378
PMCID: PMC8425331
DOI: 10.1111/1754-9485.13038

Multicenter Study

Predictors of patient preference for either whole body magnetic resonance imaging (WB-MRI) or CT/ PET-CT for staging colorectal or lung cancer

Anne Miles et al. J Med Imaging Radiat Oncol. 2020 Aug.

. 2020 Aug;64(4):537-545.

doi: 10.1111/1754-9485.13038. Epub 2020 May 14.

Authors

Collaborators

STREAMLINE investigators:
A Aboagye, L Agoramoorthy, S Ahmed, A Amadi, G Anand, G Atkin, A Austria, S Ball, F Bazari, R Beable, H Beedham, T Beeston, N Bharwani, G Bhatnagar, A Bhowmik, L Blakeway, D Blunt, P Boavida, D Boisfer, D Breen, S Burke, R Butawan, Y Campbell, E Chang, D Chao, S Chukundah, B Collins, C Collins, V Conteh, J Couture, J Crosbie, H Curtis, A Daniel, L Davis, K Desai, M Duggan, S Ellis, C Elton, A Engledow, C Everitt, S Ferdous, A Frow, M Furneaux, N Gibbons, R Glynne-Jones, A Gogbashian, S Gourtsoyianni, A Green, Laura Green, Liz Green, A Groves, A Guthrie, E Hadley, A Hameeduddin, G Hanid, S Hans, B Hans, A Higginson, L Honeyfield, H Hughes, J Hughes, L Hurl, E Isaac, M Jackson, A Jalloh, R Jannapureddy, A Jayme, A Johnson, E Johnson, P Julka, J Kalasthry, E Karapanagiotou, S Karp, C Kay, J Kellaway, S Khan, D Koh, T Light, P Limbu, S Lock, I Locke, T Loke, A Lowe, N Lucas, S Maheswaran, S Mallett, E Marwood, J McGowan, F Mckirdy, T Mills-Baldock, T Moon, V Morgan, S Nasseri, P Nichols, C Norman, E Ntala, A Nunes, A Obichere, J O'Donohue, I Olaleye, A Onajobi, T O'Shaughnessy, A Padhani, H Pardoe, W Partridge, U Patel, K Perry, W Piga, D Prezzi, K Prior, S Punwani, J Pyers, H Rafiee, F Rahman, I Rajanpandian, S Ramesh, S Raouf, K Reczko, A Reinhardt, D Robinson, P Russell, K Sargus, E Scurr, K Shahabuddin, A Sharp, B Shepherd, K Shiu, H Sidhu, I Simcock, C Simeon, A Smith, D Smith, D Snell, J Spence, R Srirajaskanthan, V Stachini, S Stegner, J Stirling, N Strickland, K Tarver, J Teague, M Thaha, M Train, S Tulmuntaha, N Tunariu, K van Ree, A Verjee, C Wanstall, S Weir, S Wijeyekoon, J Wilson, S Wilson, T Win, L Woodrow, D Yu

Affiliations

¹ Department of Psychological Sciences, Birkbeck, University of London, London, UK.
² Centre for Medical Imaging, University College London, Charles Bell House, UK.
³ Cancer Research UK, University College London Clinical Trials Centre, London, UK.
⁴ UCL Cancer Institute, Paul O Gorman Building, London, UK.
⁵ Cancer Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, Strand, London, UK.
⁶ Lungs for Living Research Centre, UCL Respiratory, Division of Medicine, University College London, London, UK.
⁷ Department of Thoracic Medicine, UCLH and Lungs for Living Research Centre, UCL Respiratory, University College London, London, UK.
⁸ Cancer patient representatives, c/o National Cancer Research Institute, London, UK.
⁹ Research Department of Applied Health Research, University College London, London, UK.
¹⁰ Department of Surgery and Cancer, Imperial College London, Kensington, London, UK.

PMID: 32410378
PMCID: PMC8425331
DOI: 10.1111/1754-9485.13038

Abstract

Introduction: Whole body magnetic resonance imaging (WB-MRI) may be more efficient in staging cancers, but can be harder for patients to tolerate. We examined predictors of patient preference for WB-MRI vs. CT/ PET-CT for staging colorectal or lung cancer.

Methods: Patients recruited prospectively to two multicentre trials comparing diagnostic accuracy of WB-MRI with standard staging scans were sent two questionnaires: the first, administered at trial registration, captured demographics, educational level and comorbidities; the second, administered after staging completion, measured emotional distress (GHQ-12), positive mood (PANAS), perceived scan burden, patients' beliefs about WB-MRI, and preference for either WB-MRI or CT (colorectal trial), WB-MRI or PET-CT (lung trial). Preference for WB-MRI or CT/ PET-CT was analysed using logistic regression.

Results: Baseline and post-staging questionnaires were completed by 97 and 107 patients, respectively. Overall, 56/107 (52%) preferred WB-MRI over standard scans and were more likely to have no additional comorbidities, higher positive mood, greater awareness of potential benefits of WB-MRI and lower levels of perceived WB-MRI scan burden. In adjusted analyses, only awareness of potential WB-MRI benefits remained a significant predictor (OR: 1.516, 95% CIs 1.006-2.284, P = 0.047). Knowledge that WB-MRI does not use radiation predicted preference (adjusted OR: 3.018, 95% CIs 1.099-8.288, P = 0.032), although only 45/107 (42%) patients were aware of this attribute.

Conclusions: A small majority of patients undergoing staging of colorectal or lung cancer prefer WB-MRI to CT/ PET-CT. Raising awareness of the potential benefits of WB-MRI, notably lack of ionizing radiation, could influence preference.

Keywords: X-ray computed; cancer; magnetic resonance imaging; patient preference; positron emission tomography; tomography.

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Figures

**Fig. 1**
Flow diagram of participants through the study (March 2013–July 2015).

See this image and copyright information in PMC

References

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Predictors of patient preference for either whole body magnetic resonance imaging (WB-MRI) or CT/ PET-CT for staging colorectal or lung cancer

Collaborators

Affiliations

Predictors of patient preference for either whole body magnetic resonance imaging (WB-MRI) or CT/ PET-CT for staging colorectal or lung cancer

Authors

Collaborators

Affiliations

Abstract

Figures

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical