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Observational Study
. 2020 May 14;24(1):219.
doi: 10.1186/s13054-020-02939-x.

Patients with COVID-19 in 19 ICUs in Wuhan, China: a cross-sectional study

Yuan Yu  1 , Dan Xu  1 , Shouzhi Fu  2 , Jun Zhang  3 , Xiaobo Yang  1 , Liang Xu  4 , Jiqian Xu  1 , Yongran Wu  1 , Chaolin Huang  5 , Yaqi Ouyang  1 , Luyu Yang  2 , Minghao Fang  6 , Hongwen Xiao  7 , Jing Ma  8 , Wei Zhu  9 , Song Hu  10 , Quan Hu  11 , Daoyin Ding  11 , Ming Hu  12 , Guochao Zhu  13 , Weijiang Xu  14 , Jun Guo  15 , Jinglong Xu  15 , Haitao Yuan  16 , Bin Zhang  17 , Zhui Yu  18 , Dechang Chen  19 , Shiying Yuan  20 , You Shang  21
Affiliations
Observational Study

Patients with COVID-19 in 19 ICUs in Wuhan, China: a cross-sectional study

Yuan Yu et al. Crit Care. .

Abstract

Background: A COVID-19 outbreak started in Wuhan, China, last December and now has become a global pandemic. The clinical information in caring of critically ill patients with COVID-19 needs to be shared timely, especially under the situations that there is still a largely ongoing spread of COVID-19 in many countries.

Methods: A multicenter prospective observational study investigated all the COVID-19 patients received in 19 ICUs of 16 hospitals in Wuhan, China, over 24 h between 8 AM February 2h and 8 AM February 27, 2020. The demographic information, clinical characteristics, vital signs, complications, laboratory values, and clinical managements of the patients were studied.

Results: A total of 226 patients were included. Their median (interquartile range, IQR) age was 64 (57-70) years, and 139 (61.5%) patients were male. The duration from the date of ICU admission to the study date was 11 (5-17) days, and the duration from onset of symptoms to the study date was 31 (24-36) days. Among all the patients, 155 (68.6%) had at least one coexisting disease, and their sequential organ failure assessment score was 4 (2-8). Organ function damages were found in most of the patients: ARDS in 161 (71.2%) patients, septic shock in 34 (15.0%) patients, acute kidney injury occurred in 57 (25.2%) patients, cardiac injury in 61 (27.0%) patients, and lymphocytopenia in 160 (70.8%) patients. Of all the studied patients, 85 (37.6%) received invasive mechanical ventilation, including 14 (6.2%) treated with extracorporeal membrane oxygenation (ECMO) at the same time, 20 (8.8%) received noninvasive mechanical ventilation, and 24 (10.6%) received continuous renal replacement therapy. By April 9, 2020, 87 (38.5%) patients were deceased and 15 (6.7%) were still in the hospital.

Conclusions: Critically ill patients with COVID-19 are associated with a higher risk of severe complications and need to receive an intensive level of treatments. COVID-19 poses a great strain on critical care resources in hospitals.

Trial registration: Chinese Clinical Trial Registry, ChiCTR2000030164. Registered on February 24, 2020, http://www.chictr.org.cn/edit.aspx?pid=49983&htm=4.

Keywords: COVID-19; Complications; Critically ill patients; Epidemic.

PubMed Disclaimer

Conflict of interest statement

All the authors state that there are no conflicts of interest related to this study.

Figures

Fig. 1
Fig. 1
Identified bacteria in patients with hospital-acquired pneumonia. CRAB, carbapenem-resistant Acinetobacter baumannii; MRSA, methicillin-resistant Staphylococcus aureus
Fig. 2
Fig. 2
Chest computed tomographic imaging of the lungs performed on February 26, 2020, showed ground-glass opacity in the bilateral lungs on day 10 after symptom onset
See this image and copyright information in PMC

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