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. 2020 Jan 3:2020:5798146.
doi: 10.1155/2020/5798146. eCollection 2020.

Anabolic Hormone Deficiencies in Heart Failure with Reduced or Preserved Ejection Fraction and Correlation with Plasma Total Antioxidant Capacity

Antonio Mancini  1 , Angela Maria Rita Fuvuzzi  2 , Carmine Bruno  1 , Maria Anna Nicolazzi  2 , Edoardo Vergani  1 , Nunzia Ciferri  1 , Andrea Silvestrini  3 , Elisabetta Meucci  3 , Nicola Nicolotti  4 , Roberta D'Assante  5 , Antonio Cittadini  5
Affiliations

Anabolic Hormone Deficiencies in Heart Failure with Reduced or Preserved Ejection Fraction and Correlation with Plasma Total Antioxidant Capacity

Antonio Mancini et al. Int J Endocrinol. .

Erratum in

Abstract

Background: While anabolic hormone deficit is a common finding in heart failure with reduced ejection fraction (HFrEF), few data are available in heart failure with preserved ejection fraction (HFpEF).

Methods: Blood samples were collected for metabolic (total cholesterol, HDL cholesterol, LDL cholesterol, creatinine, and glucose) and hormonal (IGF-1, DHEA-S, TSH, fT3, fT4, and T) determination, comparing 30 patients with HFpEF and 20 patients with HFrEF. Total antioxidant capacity was evaluated by using the spectrophotometric method using the latency time in the appearance of the radical species of a chromogen (LAG, sec) as a parameter proportional to antioxidant content of the sample. Echocardiographic parameters were also assessed in the two groups.

Results: A high prevalence of testosterone (32% in HFrEF and 72% in HFpEF, p < 0.05) and DHEA-S deficiencies was observed in HFpEF patients. Echocardiographic parameters did not correlate with hormone values. A significant direct correlation between T (r 2 = 0.25, p < 0.05) and DHEA-S (r 2 = 0.19, p < 0.05) with LAG was observed only in HFpEF.

Conclusion: Anabolic hormone deficiency is clearly shown in HFpEF, as already known in HFrEF. Although longitudinal studies are required to confirm the prognostic value of this observation, our data suggest different mechanisms in modulating antioxidants in the two conditions, with possible therapeutic implications.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Percentage of patients with low testosterone levels in the two forms of heart failure (preserved or reduced ejection fraction, HFpEF and HFrEF, respectively).
Figure 2
Figure 2
Graphical representation of correlation between LAG (latency time in the appearance of radical species, see text for the method), as a parameter of total antioxidant capacity and levels of testosterone T (a) or DHEA-S (b) in patients with heart failure with preserved ejection fraction (HFpEF).
See this image and copyright information in PMC

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