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Review
. 2020 Feb 20;5(1):29-33.
doi: 10.1136/svn-2019-000274. eCollection 2020.

Coagulopathy reversal in intracerebral haemorrhage

Alexander Jacob Sweidan  1 , Navneet Kaur Singh  2 , Joseph Luke Conovaloff  1 , Matthew Bower  1 , Leonid I Groysman  1 , Mohammad Shafie  1 , Wengui Yu  1
Affiliations
Review

Coagulopathy reversal in intracerebral haemorrhage

Alexander Jacob Sweidan et al. Stroke Vasc Neurol. .

Abstract

As intracerebral hemorrahge becomes more frequent as a result of an aging population with greater comorbidities, rapid identification and reversal of precipitators becomes increasingly paramount. The aformentioned population will ever more likely be on some form of anticoagulant therapy. Understanding the mechanisms of these agents and means by which to reverse them early on is critical in managing the acute intracerebral hemorrhage.

Keywords: anticoagulation; cerebral hemorrhage; coagulopathy reversal; hemorrhagic stroke.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Algorithm for the reversal of specific anticoagulants, including direct thrombin inhibitors, direct factor Xa inhibitors, warfarin and heparin. FFP, fresh frozen plasma; 4F-PCC, four factor prothrombin complex concentrate;ICH, intracerebral haemorrhage; INR, internationalnormalised ratio; IU, international unit; IV, intravenous; LMWH, low-molecular weight heparin; PCC, prothrombin complex concentrate.
See this image and copyright information in PMC

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