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. 2020 Jul-Aug;14(4):561-565.
doi: 10.1016/j.dsx.2020.04.050. Epub 2020 May 7.

Vitamin D concentrations and COVID-19 infection in UK Biobank

Claire E Hastie  1 , Daniel F Mackay  1 , Frederick Ho  1 , Carlos A Celis-Morales  2 , Srinivasa Vittal Katikireddi  1 , Claire L Niedzwiedz  1 , Bhautesh D Jani  1 , Paul Welsh  3 , Frances S Mair  1 , Stuart R Gray  3 , Catherine A O'Donnell  1 , Jason Mr Gill  3 , Naveed Sattar  4 , Jill P Pell  5
Affiliations

Vitamin D concentrations and COVID-19 infection in UK Biobank

Claire E Hastie et al. Diabetes Metab Syndr. 2020 Jul-Aug.

Erratum in

Abstract

Background and aims: COVID-19 and low levels of vitamin D appear to disproportionately affect black and minority ethnic individuals. We aimed to establish whether blood 25-hydroxyvitamin D (25(OH)D) concentration was associated with COVID-19 risk, and whether it explained the higher incidence of COVID-19 in black and South Asian people.

Methods: UK Biobank recruited 502,624 participants aged 37-73 years between 2006 and 2010. Baseline exposure data, including 25(OH)D concentration and ethnicity, were linked to COVID-19 test results. Univariable and multivariable logistic regression analyses were performed for the association between 25(OH)D and confirmed COVID-19, and the association between ethnicity and both 25(OH)D and COVID-19.

Results: Complete data were available for 348,598 UK Biobank participants. Of these, 449 had confirmed COVID-19 infection. Vitamin D was associated with COVID-19 infection univariably (OR = 0.99; 95% CI 0.99-0.999; p = 0.013), but not after adjustment for confounders (OR = 1.00; 95% CI = 0.998-1.01; p = 0.208). Ethnicity was associated with COVID-19 infection univariably (blacks versus whites OR = 5.32, 95% CI = 3.68-7.70, p-value<0.001; South Asians versus whites OR = 2.65, 95% CI = 1.65-4.25, p-value<0.001). Adjustment for 25(OH)D concentration made little difference to the magnitude of the association.

Conclusions: Our findings do not support a potential link between vitamin D concentrations and risk of COVID-19 infection, nor that vitamin D concentration may explain ethnic differences in COVID-19 infection.

Keywords: COVID-19; Ethnicity; Vitamin D.

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Conflict of interest statement

Declaration of competing interest The authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
Forest plot of factors associated with COVID-19 infection.
See this image and copyright information in PMC

Comment in

References

    1. Intensive Care National Audit and Research Centre . 2020. Covid-19 study case mix programme.
    1. Office for National Statistics 2011 Census. 2011. https://www.ons.gov.uk/census/2011census cited; Available from.
    1. John Hopkins Coronavirus Resource Centre 2020. https://coronavirus.jhu.edu/data/racial-data-transparency cited; Available from.
    1. Khunti K., Singh A.K., Pareek M., Hanif W. Is ethnicity linked to incidence or outcomes of covid-19? BMJ. 2020;369:m1548. - PubMed
    1. UK Government Ethnicity facts and figures. 2018. https://www.ethnicity-facts-figures.service.gov.uk/uk-population-by-ethn... cited; Available from.

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