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. 2020 Aug;18(8):414.
doi: 10.1038/s41579-020-0383-2.

A spike with which to beat COVID-19?

Affiliations

A spike with which to beat COVID-19?

Nawsad Alam et al. Nat Rev Microbiol. 2020 Aug.

Abstract

This month’s Under the Lens discusses how structural studies of the SARS-CoV-2 spike glycoprotein might guide a path towards a vaccine.

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Conflict of interest statement

The authors declare no competing interests.

References

    1. Walls A, et al. Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein. Cell. 2020;180:281–292. doi: 10.1016/j.cell.2020.02.058. - DOI - PMC - PubMed
    1. Shang J, et al. Structural basis of receptor recognition by SARS-CoV-2. Nature. 2020;581:221–224. doi: 10.1038/s41586-020-2179-y. - DOI - PMC - PubMed
    1. Yuan M, et al. A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2 and SARS-CoV. Science. 2020;368:630–633. doi: 10.1126/science.abb7269. - DOI - PMC - PubMed
    1. Kirchdoefer RN, et al. Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis. Sci. Rep. 2018;8:15701. doi: 10.1038/s41598-018-34171-7. - DOI - PMC - PubMed
    1. Jiang S, et al. Receptor-binding domains of spike proteins of emerging or re-emerging viruses as targets for development of antiviral vaccines. Emerg. Microbes Infect. 2012;1:e3. doi: 10.1038/emi.2012.1. - DOI - PMC - PubMed

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