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Comment
. 2020 Jul;142(1):66-67.
doi: 10.1111/acps.13184.

Pneumonia risk: approximately one-third is due to clozapine and two-thirds is due to treatment-resistant schizophrenia

A G Villasante-Tezanos  1 , C Rohde  2   3   4 , J Nielsen  4 , J de Leon  5
Affiliations
Comment

Pneumonia risk: approximately one-third is due to clozapine and two-thirds is due to treatment-resistant schizophrenia

A G Villasante-Tezanos et al. Acta Psychiatr Scand. 2020 Jul.
No abstract available

Keywords: clozapine/adverse effects; clozapine/toxicity; infection; pneumonia; respiratory aspiration.

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References

    1. Papola D, Ostuzzi G, Gastaldon C et al. Antipsychotic use and risk of life-threatening medical events: umbrella review of observational studies. Acta Psychiatr Scand 2019;140:227-243.
    1. De Leon J, Sanz EJ, De Las Cuevas C. Data from the World Health Organization's pharmacovigilance database supports the prominent role of pneumonia in mortality associated with clozapine adverse drug reactions. Schizophr Bull 2020;46:1-3.
    1. Cicala G, Barbieri MA, Spina E, de Leon J. A comprehensive review of swallowing difficulties and dysphagia associated with antipsychotics in adults. Expert Rev Clin Pharmacol 2019;12:219-234.
    1. Woodward M. Epidemiology. Study design and data analyses. Boca Raton, FL: Chapman & Hall/CRC, 1999:132-137.
    1. Rohde C, Siskind D, de Leon J, Nielsen J. Antipsychotic medication exposure, clozapine, and pneumonia: results from a self-controlled study. Acta Psychiatr Scand 2020;https://doi.org/10.1111/acps.13142. [Epub ahead of print].

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