Patients with diabetes are at higher risk for severe illness from COVID-19

G Targher¹, A Mantovani², X-B Wang³, H-D Yan⁴, Q-F Sun⁵, K-H Pan⁶, C D Byrne⁷, K I Zheng⁸, Y-P Chen⁹, M Eslam¹⁰, J George¹⁰, M-H Zheng¹¹

Affiliations

¹ Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy. Electronic address: giovanni.targher@univr.it.
² Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy.
³ Department of Critical Care Medicine, Wenzhou Central Hospital, Wenzhou, China.
⁴ Department of Hepatology, Key Laboratory of Diagnosis and Treatment of Digestive System Tumours of Zhejiang Province, Hwamei Hospital, Ningbo No.2 Hospital, University of Chinese Academy of Sciences, Ningbo, China.
⁵ Department of Infectious Diseases, Ruian People's Hospital, Wenzhou, China.
⁶ Department of Radiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
⁷ Southampton National Institute for Health Research Biomedical Research Centre, University Hospital Southampton, Southampton General Hospital, Southampton, UK.
⁸ MAFLD Research Centre, Department of Hepatology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
⁹ MAFLD Research Centre, Department of Hepatology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China; Institute of Hepatology, Wenzhou Medical University, Wenzhou, China.
¹⁰ Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Sydney, Australia.
¹¹ MAFLD Research Centre, Department of Hepatology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China; Institute of Hepatology, Wenzhou Medical University, Wenzhou, China; Laboratory of Diagnosis and Treatment for The Development of Chronic Liver Disease in Zhejiang Province, Wenzhou, China. Electronic address: zhengmh@wmu.edu.cn.

PMID: 32416321
PMCID: PMC7255326
DOI: 10.1016/j.diabet.2020.05.001

Patients with diabetes are at higher risk for severe illness from COVID-19

G Targher et al. Diabetes Metab. 2020 Sep.

. 2020 Sep;46(4):335-337.

doi: 10.1016/j.diabet.2020.05.001. Epub 2020 May 13.

Authors

G Targher¹, A Mantovani², X-B Wang³, H-D Yan⁴, Q-F Sun⁵, K-H Pan⁶, C D Byrne⁷, K I Zheng⁸, Y-P Chen⁹, M Eslam¹⁰, J George¹⁰, M-H Zheng¹¹

Affiliations

¹ Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy. Electronic address: giovanni.targher@univr.it.
² Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy.
³ Department of Critical Care Medicine, Wenzhou Central Hospital, Wenzhou, China.
⁴ Department of Hepatology, Key Laboratory of Diagnosis and Treatment of Digestive System Tumours of Zhejiang Province, Hwamei Hospital, Ningbo No.2 Hospital, University of Chinese Academy of Sciences, Ningbo, China.
⁵ Department of Infectious Diseases, Ruian People's Hospital, Wenzhou, China.
⁶ Department of Radiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
⁷ Southampton National Institute for Health Research Biomedical Research Centre, University Hospital Southampton, Southampton General Hospital, Southampton, UK.
⁸ MAFLD Research Centre, Department of Hepatology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
⁹ MAFLD Research Centre, Department of Hepatology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China; Institute of Hepatology, Wenzhou Medical University, Wenzhou, China.
¹⁰ Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Sydney, Australia.
¹¹ MAFLD Research Centre, Department of Hepatology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China; Institute of Hepatology, Wenzhou Medical University, Wenzhou, China; Laboratory of Diagnosis and Treatment for The Development of Chronic Liver Disease in Zhejiang Province, Wenzhou, China. Electronic address: zhengmh@wmu.edu.cn.

PMID: 32416321
PMCID: PMC7255326
DOI: 10.1016/j.diabet.2020.05.001

Abstract

•
It is currently uncertain whether people with diabetes are at higher risk of severe illness from coronavirus disease 2019 (COVID-19).
•
We found that diabetes was associated with an approximately 4-fold increased risk of having severe/critical COVID-19 illness.
•
This association was independent of age, sex, obesity, hypertension and smoking.
•
These findings highlight the urgent need for a multidisciplinary team-based approach to management of this patient population.

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Comment in

Elevated fasting blood glucose at admission is associated with poor outcomes in patients with COVID-19.
Liu S, Zhang B, You J, Chen L, Yuan H, Zhang S. Liu S, et al. Diabetes Metab. 2021 Mar;47(2):101189. doi: 10.1016/j.diabet.2020.08.004. Epub 2020 Sep 4. Diabetes Metab. 2021. PMID: 32896652 Free PMC article. No abstract available.

References

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Patients with diabetes are at higher risk for severe illness from COVID-19

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Patients with diabetes are at higher risk for severe illness from COVID-19

Authors

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Medical