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. 2020;20(16):1423-1433.
doi: 10.2174/1568026620999200517043137.

Novel Drugs Targeting the SARS-CoV-2/COVID-19 Machinery

Ariane Sternberg  1 , Dwight L McKee  2 , Cord Naujokat  3
Affiliations

Novel Drugs Targeting the SARS-CoV-2/COVID-19 Machinery

Ariane Sternberg et al. Curr Top Med Chem. 2020.

Abstract

Like other human pathogenic viruses, coronavirus SARS-CoV-2 employs sophisticated macromolecular machines for viral host cell entry, genome replication and protein processing. Such machinery encompasses SARS-CoV-2 envelope spike (S) glycoprotein required for host cell entry by binding to the ACE2 receptor, viral RNA-dependent RNA polymerase (RdRp) and 3-chymotrypsin-like main protease (3Clpro/Mpro). Under the pressure of the accelerating COVID-19 pandemic caused by the outbreak of SARS-CoV-2 in Wuhan, China in December 2019, novel and repurposed drugs were recently designed and identified for targeting the SARS-CoV-2 reproduction machinery, with the aim to limit the spread of SARS-CoV-2 and morbidity and mortality due to the COVID-19 pandemic.

Keywords: 3Clpro; COVID-19; Camostat; Coronavirus SARS-CoV-2; RNA polymerase; Remdesivir; S protein; α-Ketoamides.

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