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Multicenter Study
. 2020 Jul 1:212:107986.
doi: 10.1016/j.drugalcdep.2020.107986. Epub 2020 Apr 26.

Alcohol and marijuana co-use: Consequences, subjective intoxication, and the operationalization of simultaneous use

Alexander W Sokolovsky  1 , Rachel L Gunn  2 , Lauren Micalizzi  3 , Helene R White  4 , Kristina M Jackson  5
Affiliations
Multicenter Study

Alcohol and marijuana co-use: Consequences, subjective intoxication, and the operationalization of simultaneous use

Alexander W Sokolovsky et al. Drug Alcohol Depend. .

Abstract

Background: Alcohol and marijuana are frequently co-used with overlapping effects. However, the absence of consistent operational definitions delineating simultaneous alcohol and marijuana use (SAM) from concurrent use (CAM) challenges consistent inferences about these behaviors. This study first examined whether daily alcohol and marijuana co-use predicted substance-use related consequences and subjective intoxication; and then evaluated whether competing operationalizations of SAM and CAM were associated with differences in these outcomes on co-use days.

Methods: A sample of 341 young adult college students who reported past-month use of both alcohol and marijuana "at the same time so that their effects overlapped" completed a two-wave survey with paired 28-day daily experience sampling bursts examining alcohol and marijuana co-use. Outcomes were (a) daily substance-use related consequences; and (b) daily subjective intoxication. Focal predictors were daily drinks and marijuana uses; daily co-use versus single-substance use (Aim 1) or CAM versus SAM (Aim 2); and their interaction.

Results: Participants reported more negative consequences on co-use days versus marijuana-only days and greater subjective intoxication relative to alcohol or marijuana-only days. Competing operationalizations of SAM, defined as daily co-use occurring within 1-240 min in increments of 1 min, found no difference in consequences or subjective intoxication regardless of operationalization.

Conclusion: Co-use days involve greater risk than alcohol-only or marijuana-only days. Although there was no evidence of additional daily risk from simultaneous use regardless of the timeframe used to operationalize it, investigating these effects remains challenging due to the generally small timeframe between substances on co-use days in this sample.

Keywords: Alcohol; CAM; Co-use; Concurrent; Marijuana; SAM; Simultaneous.

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Conflict of interest statement

Declaration of Competing Interest There are no conflicts of interest to declare.

Figures

Figure 1
Figure 1. Consequences and subjective intoxication on alcohol only or marijuana only versus co-use days
X axes for number of drinks (or marijuana uses) range from 1 to mean daily number of drinks (or marijuana uses) plus two standard deviations rounded up, respectively (alcohol range = 1–15; marijuana range = 1–17).
See this image and copyright information in PMC

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