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. 2020 Jun;26(6):466-469.
doi: 10.1016/j.cardfail.2020.05.006. Epub 2020 May 14.

Unique Patterns of Cardiovascular Involvement in Coronavirus Disease-2019

Nicholas S Hendren  1 , Justin L Grodin  1 , Mark H Drazner  2
Affiliations

Unique Patterns of Cardiovascular Involvement in Coronavirus Disease-2019

Nicholas S Hendren et al. J Card Fail. 2020 Jun.
No abstract available

Keywords: COVID-19; Coronavirus disease 2019; acute COVID-19 cardiovascular syndrome.

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Conflict of interest statement

Declaration of Competing Interest NH and MD report no relevant conflicts of interest or disclosures. JG reports consulting income from Pfizer, Inc, and Eidos Therapeutics.

Figures

Fig 1
Fig. 1
Spectrum of symptomatic coronavirus disease-2019 (COVID-19) clinical presentations. Spectrum of pulmonary, cardiac and noncardiopulmonary disease for hospitalized patients with the acute COVID-19 cardiovascular syndrome (ACovCS). Notably asymptomatic severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection may represent that greatest prevalence of infected patients; however, the majority of symptomatic patients have respiratory symptoms without cardiac involvement. Predominate cardiac syndromes in patients hospitalized with COVID-19 represent a less common clinical phenotype while patients with mixed pulmonary and cardiac disease represent a phenotypic overlap with multiorgan injury that occurs in a sizable minority of hospitalized patients. ACovCS encompasses cardiac manifestations and myocardial injury for both cardiac predominate and mixed disease. Noncardiopulmonary predominate disease represents a variety of other presentations such as altered mental status (neurologic), isolated deep vein thrombosis (hypercoagulable), diarrhea (gastrointestinal), and rash (dermatologic). ACS, acute coronary syndrome; AMI, acute myocardial injury; ARDS, acute respiratory distress syndrome; CAD, coronary artery disease; COVID-19, coronavirus disease-2019; MI, myocardial infarction; NSTEMI, non–ST-elevation myocardial infarction; PE, pulmonary embolism; STEMI, ST-elevation myocardial infarction; VF, ventricular fibrillation; VT, ventricular tachycardia.
Fig 2
Fig. 2
Potential factors influencing the variability of coronavirus disease-2019 (COVID-19). Factors influencing severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection penetrance and disease course remain unclear. Several factors are hypothesized to influence the clinical phenotype and illness severity of COVID-19 including the presence of a coinfection, environmental factors, host factors, host genetics, and viral factors, among others. ACE2, angiotensin-converting enzyme 2; ADAM17, ADAM metallopeptidase domain 17; CV, cardiovascular; ICU, intensive care unit; TMPRSS2, transmembrane serine protease 2.
See this image and copyright information in PMC

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