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Review
. 2020 Sep;14(5):e1900138.
doi: 10.1002/prca.201900138. Epub 2020 Jun 22.

Clinical Application of Mass Spectrometry-Based Proteomics in Lung Cancer Early Diagnosis

Roberto Gasparri  1 , Giulia Sedda  1 , Roberta Noberini  2 , Tiziana Bonaldi  2 , Lorenzo Spaggiari  1   3
Affiliations
Review

Clinical Application of Mass Spectrometry-Based Proteomics in Lung Cancer Early Diagnosis

Roberto Gasparri et al. Proteomics Clin Appl. 2020 Sep.

Abstract

The current knowledge on proteomic biomarker analysis for the early diagnosis of lung cancer is summarized, underlining the diversity among the results and the current interest in translating research results into clinical practice. A MEDLINE/PubMed literature search to retrieve all the papers published in the last 10 years is performed. Proteomics studies on lung cancer have gathered evidence on the potential role of biomarkers in early diagnosis. Although promising, none of them have proved to be sufficiently reliable to achieve validation. Future research should evolve toward a multipanel analysis of proteins, considering the possibility that individual biomarkers might not be specific enough to diagnose lung cancer, but could be related to oncological conditions.

Keywords: lung cancer; proteomics; translational medicine.

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