Imaging Mechanisms of Disease Progression in Multiple Sclerosis: Beyond Brain Atrophy

Francesca Bagnato¹, Susan A Gauthier², Cornelia Laule³, George R Wayne Moore⁴, Riley Bove⁵, Zhengxin Cai⁶, Julien Cohen-Adad⁷, Daniel M Harrison⁸, Eric C Klawiter⁹, Sarah A Morrow¹⁰, Gülin Öz¹¹, William D Rooney¹², Seth A Smith¹³, Peter A Calabresi¹⁴, Roland G Henry¹⁵, Jiwon Oh^{14

16}, Daniel Ontaneda¹⁷, Daniel Pelletier¹⁸, Daniel S Reich¹⁹, Russell T Shinohara²⁰, Nancy L Sicotte²¹; NAIMS Cooperative¹

Affiliations

¹ Neuroimaging Unit, Neuroimmunology Division, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN.
² Judith Jaffe Multiple Sclerosis Center, Department of Neurology, Feil Family Brain and Mind Institute, and Department of Radiology, Weill Cornell Medicine, New York, NY.
³ Department of Radiology, Pathology, and Laboratory Medicine, Department of Physics and Astronomy, and International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, British Columbia, Canada.
⁴ Department of Pathology and Laboratory Medicine, and International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, British Columbia, Canada.
⁵ Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA.
⁶ Department of Radiology and Biomedical Imaging, PET Center, Yale University, New Haven, CT.
⁷ NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal and Functional Neuroimaging Unit, CRIUGM, University of Montreal, Montreal, Quebec, Canada.
⁸ Department of Neurology, University of Maryland School of Medicine, Baltimore, MD.
⁹ Massachusetts General Hospital, Harvard Medical School, Boston, MA.
¹⁰ Department of Clinical Neurological Sciences, University of Western Ontario, London, Ontario, Canada.
¹¹ Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN.
¹² Advanced Imaging Research Center, Departments of Biomedical Engineering, Neurology, and Behavioral Neuroscience, Oregon Health & Science University, Portland, OR.
¹³ Radiology and Radiological Sciences and Vanderbilt University Imaging Institute, Vanderbilt University Medical Center, and Biomedical Engineering, Vanderbilt University, Nashville, TN.
¹⁴ Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD.
¹⁵ Departments of Neurology, Radiology and Biomedical Imaging, and the UC San Francisco & Berkeley Bioengineering Graduate Group, University of California San Francisco, San Francisco, CA.
¹⁶ Division of Neurology, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
¹⁷ Mellen Center for Multiple Sclerosis, Neurological Institute, Cleveland Clinic, Cleveland, OH.
¹⁸ Department of Neurology, University of Southern California Keck School of Medicine, Los Angeles, CA.
¹⁹ Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD.
²⁰ Department of Biostatistics, Epidemiology, and Informatics, Penn Statistics in Imaging and Visualization Center, University of Pennsylvania, Philadelphia, PA.
²¹ Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA.

PMID: 32418324
DOI: 10.1111/jon.12700

Review

Imaging Mechanisms of Disease Progression in Multiple Sclerosis: Beyond Brain Atrophy

Francesca Bagnato et al. J Neuroimaging. 2020 May.

. 2020 May;30(3):251-266.

doi: 10.1111/jon.12700.

Authors

Affiliations

¹ Neuroimaging Unit, Neuroimmunology Division, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN.
² Judith Jaffe Multiple Sclerosis Center, Department of Neurology, Feil Family Brain and Mind Institute, and Department of Radiology, Weill Cornell Medicine, New York, NY.
³ Department of Radiology, Pathology, and Laboratory Medicine, Department of Physics and Astronomy, and International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, British Columbia, Canada.
⁴ Department of Pathology and Laboratory Medicine, and International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, British Columbia, Canada.
⁵ Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA.
⁶ Department of Radiology and Biomedical Imaging, PET Center, Yale University, New Haven, CT.
⁷ NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal and Functional Neuroimaging Unit, CRIUGM, University of Montreal, Montreal, Quebec, Canada.
⁸ Department of Neurology, University of Maryland School of Medicine, Baltimore, MD.
⁹ Massachusetts General Hospital, Harvard Medical School, Boston, MA.
¹⁰ Department of Clinical Neurological Sciences, University of Western Ontario, London, Ontario, Canada.
¹¹ Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN.
¹² Advanced Imaging Research Center, Departments of Biomedical Engineering, Neurology, and Behavioral Neuroscience, Oregon Health & Science University, Portland, OR.
¹³ Radiology and Radiological Sciences and Vanderbilt University Imaging Institute, Vanderbilt University Medical Center, and Biomedical Engineering, Vanderbilt University, Nashville, TN.
¹⁴ Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD.
¹⁵ Departments of Neurology, Radiology and Biomedical Imaging, and the UC San Francisco & Berkeley Bioengineering Graduate Group, University of California San Francisco, San Francisco, CA.
¹⁶ Division of Neurology, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
¹⁷ Mellen Center for Multiple Sclerosis, Neurological Institute, Cleveland Clinic, Cleveland, OH.
¹⁸ Department of Neurology, University of Southern California Keck School of Medicine, Los Angeles, CA.
¹⁹ Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD.
²⁰ Department of Biostatistics, Epidemiology, and Informatics, Penn Statistics in Imaging and Visualization Center, University of Pennsylvania, Philadelphia, PA.
²¹ Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA.

PMID: 32418324
DOI: 10.1111/jon.12700

Abstract

Clinicians involved with different aspects of the care of persons with multiple sclerosis (MS) and scientists with expertise on clinical and imaging techniques convened in Dallas, TX, USA on February 27, 2019 at a North American Imaging in Multiple Sclerosis Cooperative workshop meeting. The aim of the workshop was to discuss cardinal pathobiological mechanisms implicated in the progression of MS and novel imaging techniques, beyond brain atrophy, to unravel these pathologies. Indeed, although brain volume assessment demonstrates changes linked to disease progression, identifying the biological mechanisms leading up to that volume loss are key for understanding disease mechanisms. To this end, the workshop focused on the application of advanced magnetic resonance imaging (MRI) and positron emission tomography (PET) imaging techniques to assess and measure disease progression in both the brain and the spinal cord. Clinical translation of quantitative MRI was recognized as of vital importance, although the need to maintain a relatively short acquisition time mandated by most radiology departments remains the major obstacle toward this effort. Regarding PET, the panel agreed upon its utility to identify ongoing pathological processes. However, due to costs, required expertise, and the use of ionizing radiation, PET was not considered to be a viable option for ongoing care of persons with MS. Collaborative efforts fostering robust study designs and imaging technique standardization across scanners and centers are needed to unravel disease mechanisms leading to progression and discovering medications halting neurodegeneration and/or promoting repair.

Keywords: Axons; chronic inflammation; magnetic resonance imaging; multiple sclerosis; neurodegeneration.

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References

1. Lassmann H. Multiple sclerosis pathology. Cold Spring Harb Perspect Med 2018;8:a028936.
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1. Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 1983;33:1444-52.

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Imaging Mechanisms of Disease Progression in Multiple Sclerosis: Beyond Brain Atrophy

Affiliations

Imaging Mechanisms of Disease Progression in Multiple Sclerosis: Beyond Brain Atrophy

Authors

Affiliations

Abstract

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical