Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Jan-Dec:28:2040206620921331.
doi: 10.1177/2040206620921331.

Nucleos(t)ide analogues and Hepatitis B virus-related hepatocellular carcinoma: A literature review

Mohamed A Abd El Aziz  1 , Rodolfo Sacco  2 , Antonio Facciorusso  2
Affiliations
Review

Nucleos(t)ide analogues and Hepatitis B virus-related hepatocellular carcinoma: A literature review

Mohamed A Abd El Aziz et al. Antivir Chem Chemother. 2020 Jan-Dec.

Abstract

Hepatitis B virus is mainly considered to cause hepatocellular carcinoma which is the fourth leading cause of cancer-related mortality worldwide. Treatment of Hepatitis B virus with nucleos(t)ide analogues can decrease the progression of the disease and subsequently decreases the incidence of hepatocellular carcinoma. In this review, we have discussed the different classes of nucleos(t)ide analogues used in the treatment of Hepatitis B virus and their relationship with the development of hepatocellular carcinoma. Furthermore, we discussed the effect of treatment of Hepatitis B virus with Nucleoside analogues (NAs) before, during and after surgery, chemoembolization, radiofrequency ablation, and chemotherapy for the treatment of hepatocellular carcinoma.

Keywords: Hepatitis B virus; Hepatocellular carcinoma; adefovir; entecavir; lamivudine; nucleos(t)ide analogues; telbivudine interferon; tenofovir.

PubMed Disclaimer

References

    1. Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018; 68: 394–424. DOI: 10.3322/caac.21492. - PubMed
    1. Akinyemiju T, Abera S, Ahmed M, et al. The burden of primary liver cancer and underlying etiologies from 1990 to 2015 at the global, regional, and national level: results from the global burden of disease study 2015. JAMA Oncol 2017; 3: 1683–1691. - PMC - PubMed
    1. Mittal S, El-Serag HB. Epidemiology of hepatocellular carcinoma: consider the population. J Clin Gastroenterol 2013; 47: S2–6. - PMC - PubMed
    1. Ma L, Alla NR, Li X, et al. Mother-to-child transmission of HBV: review of current clinical management and prevention strategies. Rev Med Virol 2014; 24: 396–406.DOI: 10.1002/rmv.1801. - PubMed
    1. Piot P, Goilav C, Kegels E. Hepatitis B: transmission by sexual contact and needle sharing. Vaccine 1990; 8: S37–40. discussion S41–33. DOI: 10.1016/0264-410x(90)90215-8. - PubMed

MeSH terms