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. 2020 Aug;27(8):2859-2865.
doi: 10.1245/s10434-020-08621-4. Epub 2020 May 17.

The Landmark Series: Intrahepatic Cholangiocarcinoma

Jordan M Cloyd  1 , Aslam Ejaz  1 , Timothy M Pawlik  2   3
Affiliations

The Landmark Series: Intrahepatic Cholangiocarcinoma

Jordan M Cloyd et al. Ann Surg Oncol. 2020 Aug.

Abstract

Introduction: Intrahepatic cholangiocarcinoma (ICC) is an aggressive biliary tract cancer (BTC) with distinct anatomic, molecular, and clinical characteristics that distinguishes it from other BTCs.

Methods: In this landmark series review, we highlight the critical studies that have defined the surgical management of ICC, as well as several randomized controlled trials that have investigated adjuvant therapy strategies.

Results: Surgical resection is the mainstay of treatment and should involve margin-negative resection with regional lymphadenectomy. Several recently completed and ongoing randomized controlled trials are defining the indications for adjuvant therapy among patients with resected ICC.

Conclusions: In the near future, improved understanding of the molecular features of ICC should lead to newer targeted therapies as well as a more personalized approach to systemic therapy.

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References

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    1. Ejaz A, Cloyd JM, Pawlik TM. Advances in the diagnosis and treatment of patients with intrahepatic cholangiocarcinoma. Ann Surg Oncol. 2020;27:552–60. - PubMed
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