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. 2020 Sep;19(9):2267-2272.
doi: 10.1111/jocd.13493. Epub 2020 May 30.

Evaluation of safety and efficacy of booster injections of hyaluronic acid in improving the facial skin quality

Azin Ayatollahi  1 , Alireza Firooz  1 , Aniseh Samadi  1
Affiliations

Evaluation of safety and efficacy of booster injections of hyaluronic acid in improving the facial skin quality

Azin Ayatollahi et al. J Cosmet Dermatol. 2020 Sep.

Abstract

Background: Skin boosting with small particles of hyaluronic acid (HA) is a new method of skin rejuvenation.

Aim: Here, we aim to evaluate the efficacy and safety of booster injections of noncross-linked HA in improving the facial skin quality.

Methods: A total of 20 men and women age 40.15 ± 6.63 years were treated with 3 injections of noncross-linked HA (1-2 mL) with intervals of 3 weeks. Skin hydration and elasticity parameters were evaluated before intervention and 1 week and 4 months later. Facial skin improvement also evaluated using physician's global assessment score (PGA).

Results: Skin hydration increased 1 week and 4 months after last treatment, (P > .05). Skin firmness (R0) reduced significantly at week 1 and month 4 (P-value = .01 and .00). Skin-tiring effect/fatigue (R3) showed significant decrease at week 1 and month 4 (P-value = .01 and .00, respectively). Four months after last treatment skin gross elasticity (R2) and net elasticity (R5) also increased significantly (P-value = .00). Physician's global assessment 1 week and 4 months after last treatment were 2.33 ± 0.76 and 1.35 ± 0.49 out of 4, respectively. Adverse effects were mostly transient and mild in severity.

Conclusion: Booster therapy with HA is a safe and well-tolerated procedure, and results in improvement in skin elasticity and relative increase in skin hydration.

Keywords: booster injections; hyaluronic acid; skin elasticity; skin hydration.

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References

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