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Editorial
. 2020 Apr;23(Suppl 1):S1-S4.
doi: 10.4103/aian.AIAN_263_20. Epub 2020 Apr 10.

The Socially Distanced Social Animal - In The New Covid-19 Era

Lakshmi Narasimhan Ranganathan  1 , M M Arun Shivaraman  2 , Guhan Ramamurthy  1 , R Shrivarthan  1
Affiliations
Editorial

The Socially Distanced Social Animal - In The New Covid-19 Era

Lakshmi Narasimhan Ranganathan et al. Ann Indian Acad Neurol. 2020 Apr.
No abstract available

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Figures

Figure 1
Figure 1
Structure of SARS CoV-2. The spike protein, membrane and envelope protein are located on the surface of virion. The S1 and S2 subunit of the spike protein causes binding to hACE2 receptor and fusion with the host cell membrane respectively. The core of the virion consists of nucleocapsid protein and single stranded RNA (+)
Figure 2
Figure 2
Replication cycle of SARS CoV-2 in the host cell. Entry of the virus into the host cell is mediated through its interaction with Angiotensin converting enzyme receptor 2. The illustration summarises the potential sites of action of various drugs that are used in COVID -19. (A) Hydroxychloroquine and chloroquine inhibits virus entry into the cell by changing the glycosylation of ACE receptor (B) Remdesivir and Favipiravir inhibit the RNA polymerase (C) Azithromycin inhibits mRNA expression and protein production, it is also immunomodulatory and decreases inflammatory response (D) Ivermectin inhibits the interaction between the viral integrase protein (IN) and the importin (IMP) α/β1 heterodimer responsible for IN nuclear import (Not shown as a part of viral replication cycle). (E) Lopinavir, Ritonavir inhibit the protease enzyme
Figure 3
Figure 3
Neurological manifestations of SARS CoV-2
Figure 4
Figure 4
Laboratory monitoring in COVID- 19
See this image and copyright information in PMC

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