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Review
. 2020 May 6:14:1033.
doi: 10.3332/ecancer.2020.1033. eCollection 2020.

Fertility preservation in patients with BRCA mutation

Suleiman Ghunaim  1 , Ghina Ghazeeri  1 , Dalia Khalife  1 , Hatem A Azim Jr  2
Affiliations
Review

Fertility preservation in patients with BRCA mutation

Suleiman Ghunaim et al. Ecancermedicalscience. .

Abstract

Evidence suggests a likely negative impact of deleterious BRCA mutations on female fertility. Hence, different studies have aimed to address the reproductive potential and performance of fertility preservation strategies in BRCA-mutated breast cancer patients with a prime focus on their safety and efficacy. However, several uncertainties exist in many domains of this field. The aim of the current paper is to overview the reproductive potential and fertility preservation options in breast and ovarian cancer patients harbouring a BRCA mutation. We also discuss pre-implantation genetic testing in an attempt to help physicians during oncofertility counselling of these patients.

Keywords: breast cancer; counselling; oncofertility; ovarian stimulation.

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Conflict of interest statement

All authors state that this manuscript is an original work that has not been previously published in any other peer-reviewed journal, and is not currently in press or under consideration by any other journal. All authors have neither conflicts of interest to disclose nor any financial and personal relationships with other people or organisations that could influence this work.

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