Urinary biomarkers in prostate cancer: to the miRnome and beyond

Christianne Hoey^{1

2

3}, Renu Jeyapala^{4

5}, Paul C Boutros^{1

6

7

8

9

10}, Bharati Bapat^{4

5

11

12}, Stanley K Liu^{1

2

3}

Affiliations

¹ Department of Medical Biophysics, University of Toronto, Toronto, Canada.
² Department of Radiation Oncology, University of Toronto, Toronto, Canada.
³ Sunnybrook-Odette Cancer Centre, Toronto, Canada.
⁴ Institute of Medical Science, University of Toronto, Toronto, Canada.
⁵ Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Canada.
⁶ Department of Human Genetics, University of California, Los Angeles, CA, USA.
⁷ Department of Urology, University of California, Los Angeles, CA, USA.
⁸ Broad Stem Cell Research Center, University of California, Los Angeles, CA, USA.
⁹ Institute for Precision Health, University of California, Los Angeles, CA, USA.
¹⁰ Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA, USA.
¹¹ Department of Surgery and Surgical Oncology, Division of Urology, University Health Network, Toronto, Canada.
¹² Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.

PMID: 32420197
PMCID: PMC7214960
DOI: 10.21037/tau.2019.11.25

Comment

Urinary biomarkers in prostate cancer: to the miRnome and beyond

Christianne Hoey et al. Transl Androl Urol. 2020 Apr.

. 2020 Apr;9(2):843-845.

doi: 10.21037/tau.2019.11.25.

Authors

Christianne Hoey^{1

2

3}, Renu Jeyapala^{4

5}, Paul C Boutros^{1

6

7

8

9

10}, Bharati Bapat^{4

5

11

12}, Stanley K Liu^{1

2

3}

Affiliations

¹ Department of Medical Biophysics, University of Toronto, Toronto, Canada.
² Department of Radiation Oncology, University of Toronto, Toronto, Canada.
³ Sunnybrook-Odette Cancer Centre, Toronto, Canada.
⁴ Institute of Medical Science, University of Toronto, Toronto, Canada.
⁵ Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Canada.
⁶ Department of Human Genetics, University of California, Los Angeles, CA, USA.
⁷ Department of Urology, University of California, Los Angeles, CA, USA.
⁸ Broad Stem Cell Research Center, University of California, Los Angeles, CA, USA.
⁹ Institute for Precision Health, University of California, Los Angeles, CA, USA.
¹⁰ Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA, USA.
¹¹ Department of Surgery and Surgical Oncology, Division of Urology, University Health Network, Toronto, Canada.
¹² Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.

PMID: 32420197
PMCID: PMC7214960
DOI: 10.21037/tau.2019.11.25

No abstract available

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Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/tau.2019.11.25). PCB has a patent or multiple patients on prostate cancer biomarkers issued. The other authors have no conflicts of interest to declare.

Comment on

Holding a MIRror up to the robustness of the prostate cancer urinary transcriptome.
Connor AE, Jordan AC, Perry AS. Connor AE, et al. Transl Androl Urol. 2019 Dec;8(Suppl 5):S488-S490. doi: 10.21037/tau.2019.09.25. Transl Androl Urol. 2019. PMID: 32042627 Free PMC article. No abstract available.

References

1. Jeon J, Olkhov-Mitsel E, Xie H, et al. Temporal stability and prognostic biomarker potential of the prostate cancer urine transcriptome. J Natl Cancer Inst 2020;112:247-55. 10.1093/jnci/djz112 - DOI - PMC - PubMed
1. Loeb S, Vellekoop A, Ahmed HU, et al. Systematic review of complications of prostate biopsy. Eur Urol 2013;64:876-92. 10.1016/j.eururo.2013.05.049 - DOI - PubMed
1. Boutros PC, Fraser M, Harding NJ, et al. Spatial genomic heterogeneity within localized, multifocal prostate cancer. Nat Genet 2015;47:736-45. 10.1038/ng.3315 - DOI - PubMed
1. Pellegrini KL, Patil D, Douglas KJS, et al. Detection of prostate cancer-specific transcripts in extracellular vesicles isolated from post-DRE urine. Prostate 2017;77:990-9. 10.1002/pros.23355 - DOI - PMC - PubMed
1. Hessels D, Klein Gunnewiek JM, van Oort I, et al. DD3(PCA3)-based molecular urine analysis for the diagnosis of prostate cancer. Eur Urol 2003;44:8-15; discussion 15-6. 10.1016/S0302-2838(03)00201-X - DOI - PubMed

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Urinary biomarkers in prostate cancer: to the miRnome and beyond

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Urinary biomarkers in prostate cancer: to the miRnome and beyond

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