Infective Endocarditis Related to Unusual Microorganisms: A Prospective Population-Based Study

Collaborators, Affiliations

Collaborators

EI 2008 de l’AEPEI working group:
B Hoen, X Duval, F Alla, A Bouvet, S Briançon, E Cambau, M Celard, C Chirouze, N Danchin, T Doco-Lecompte, F Delahaye, J Etienne, B Iung, V Le Moing, J F Obadia, C Leport, C Poyart, M Revest, C Selton-Suty, C Strady, P Tattevin, F Vandenesch, Y Bernard, S Chocron, C Chirouze, B Hoen, P Plesiat, I Abouliatim, C De Place, P Tattevin, M Revest, P Y Donnio, F Alla, J P Carteaux, T Doco-Lecompte, C Lion, N Aissa, C Selton-Suty, B Baehrel, R Jaussaud, P Nazeyrollas, C Strady, V Vernet, E Cambau, X Duval, B Iung, P Nataf, C Chidiac, M Celard, F Delahaye, J F Obadia, F Vandenesch, H Aumaître, J M Frappier, V Le Moing, E Oziol, A Sotto, C Sportouch, C Poyart, A Bouvet, F Vandenesch, M Celard, M Bes, P Abassade, E Abrial, C Acar, N Aissa, J F Alexandra, N Amireche, D Amrein, P Andre, M Appriou, M A Arnould, P Assayag, A Atoui, F Aziza, N Baille, N Bajolle, P Battistella, S Baumard, A Ben Ali, J Bertrand, S Bialek, M Bois Grosse, M Boixados, F Borlot, A Bouchachi, O Bouche, S Bouchemal, J L Bourdon, A Bouvet, L Brasme, F Bricaire, E Brochet, J F Bruntz, A Cady, J Cailhol, M P Caplan, B Carette, J P Carteaux, O Cartry, C Cazorla, M Celard, H Chamagne, H Champagne, G Chanques, J Chastre, B Chevalier, C Chirouze, F Chometon, C Christophe, A Cohen, N Colin de Verdiere, N Danchin, V Daneluzzi, L David, P De Lentdecker, F Delahaye, V Delcey, P Deleuze, E Donal, X Duval, B Deroure, V Descotes-Genon, K Didier Petit, A Dinh, V Doat, F Duchene, F Duhoux, M Dupont, S Ederhy, O Epaulard, M Evest, J F Faucher, B Fantin, E Fauveau, T Ferry, M Fillod, T Floch, T Fraisse, J M Frapier, L Freysz, B Fumery, B Gachot, S Gallien, I Gandjbach, P Garcon, A Gaubert, J L Genoud, S Ghiglione, C Godreuil, A Grentzinger, L Groben, D Gherissi, P Guéret, A Hagege, N Hammoudi, F Heliot, P Henry, S Herson, B Hoen, P Houriez, L Hustache-Mathieu, O Huttin, S Imbert, B Iung, S Jaureguiberry, M Kaaki, A Konate, J M Kuhn, S Kural Menasche, A Lafitte, B Lafon, F Lanternier, V Le Chenault, V Le Moing, C Lechiche, S Lefèvre-Thibaut, A Lefort, A Leguerrier, J Lemoine, L Lepage, C Leport, C Lepousé, J Leroy, P Lesprit, L Letranchant, D Loisance, G Loncar, C Lorentz, P Mabo, I Magnin-Poull, T May, A Makinson, H Man, M Mansouri, O Marcxon, J P Maroni, V Masse, F Maurier, M C Meyohas, P L Michel, C Michelet, F Mechaï, O Merceron, D Messika-Zeitoun, Z Metref, V Meyssonnier, C Mezher, S Micheli, M Monsigny, S Mouly, B Mourvillier, O Nallet, P Nataf, P Nazeyrollas, V Noel, J F Obadia, E Oziol, T Papo, B Payet, A Pelletier, P Perez, J S Petit, F Philippart, E Piet, C Plainvert, B Popovic, J M Porte, P Pradier, R Ramadan, M Revest, J Richemond, M Rodermann, M Roncato, I Roigt, O Ruyer, M Saada, J Schwartz, C Selton-Suty, M Simon, B Simorre, S Skalli, F Spatz, C Strady, J Sudrial, L Tartiere, A Terrier De La Chaise, M C Thiercelin, D Thomas, M Thomas, L Toko, F Tournoux, A Tristan, J L Trouillet, L Tual, A Vahanian, F Verdier, V Vernet Garnier, V Vidal, P Weyne, M Wolff, A Wynckel, N Zannad, P Y Zinzius

Affiliations

¹ Maladies Infectieuses et Reanimation Médicale, Inserm CIC 1414, Hôpital Pontchaillou, Centre Hospitalo-Universitaire, Université Rennes 1, Rennes, France.
² UF Urgences Microbiologiques et Mycobactériologie, Département des Agents Infectieux, DMU BioGem APHP-Nord, Hôpital Lariboisière, Université de Paris, Inserm UMR 1137 IAME, Paris, France.
³ Inserm, Centre Hospitalier Régional Universitaire, Université de Lorraine, CIC-1433 Epidemiologie Clinique, Nancy, France.
⁴ Microbiologie, Hôpital Pontchaillou, Centre Hospitalo-Universitaire, Rennes, France.
⁵ Maladies Infectieuses et Tropicales, Centre Hospitalier Régional Universitaire, Université de Lorraine, Nancy, France.
⁶ Bactériologie, Centre Hospitalier Régional Universitaire, Hôpital Jean Minjoz, Besançon, France.
⁷ Microbiologie, Centre Hospitalier Universitaire, Reims, France.
⁸ Maladies Infectieuses et Tropicales, Centre Hospitalo-Universitaire, Université de Montpellier, Montpellier, France.
⁹ Inserm CIC 1425, AP-HP Nord, Hôpital Bichat, Inserm UMR-1137, IAME, Centre Hospitalo-Universitaire, Université de Paris, UFR de Médecine-Bichat, Paris, France.

PMID: 32420404
PMCID: PMC7216922
DOI: 10.1093/ofid/ofaa127

Infective Endocarditis Related to Unusual Microorganisms: A Prospective Population-Based Study

Silvia Limonta et al. Open Forum Infect Dis. 2020.

. 2020 Apr 13;7(5):ofaa127.

doi: 10.1093/ofid/ofaa127. eCollection 2020 May.

Collaborators

EI 2008 de l’AEPEI working group:
B Hoen, X Duval, F Alla, A Bouvet, S Briançon, E Cambau, M Celard, C Chirouze, N Danchin, T Doco-Lecompte, F Delahaye, J Etienne, B Iung, V Le Moing, J F Obadia, C Leport, C Poyart, M Revest, C Selton-Suty, C Strady, P Tattevin, F Vandenesch, Y Bernard, S Chocron, C Chirouze, B Hoen, P Plesiat, I Abouliatim, C De Place, P Tattevin, M Revest, P Y Donnio, F Alla, J P Carteaux, T Doco-Lecompte, C Lion, N Aissa, C Selton-Suty, B Baehrel, R Jaussaud, P Nazeyrollas, C Strady, V Vernet, E Cambau, X Duval, B Iung, P Nataf, C Chidiac, M Celard, F Delahaye, J F Obadia, F Vandenesch, H Aumaître, J M Frappier, V Le Moing, E Oziol, A Sotto, C Sportouch, C Poyart, A Bouvet, F Vandenesch, M Celard, M Bes, P Abassade, E Abrial, C Acar, N Aissa, J F Alexandra, N Amireche, D Amrein, P Andre, M Appriou, M A Arnould, P Assayag, A Atoui, F Aziza, N Baille, N Bajolle, P Battistella, S Baumard, A Ben Ali, J Bertrand, S Bialek, M Bois Grosse, M Boixados, F Borlot, A Bouchachi, O Bouche, S Bouchemal, J L Bourdon, A Bouvet, L Brasme, F Bricaire, E Brochet, J F Bruntz, A Cady, J Cailhol, M P Caplan, B Carette, J P Carteaux, O Cartry, C Cazorla, M Celard, H Chamagne, H Champagne, G Chanques, J Chastre, B Chevalier, C Chirouze, F Chometon, C Christophe, A Cohen, N Colin de Verdiere, N Danchin, V Daneluzzi, L David, P De Lentdecker, F Delahaye, V Delcey, P Deleuze, E Donal, X Duval, B Deroure, V Descotes-Genon, K Didier Petit, A Dinh, V Doat, F Duchene, F Duhoux, M Dupont, S Ederhy, O Epaulard, M Evest, J F Faucher, B Fantin, E Fauveau, T Ferry, M Fillod, T Floch, T Fraisse, J M Frapier, L Freysz, B Fumery, B Gachot, S Gallien, I Gandjbach, P Garcon, A Gaubert, J L Genoud, S Ghiglione, C Godreuil, A Grentzinger, L Groben, D Gherissi, P Guéret, A Hagege, N Hammoudi, F Heliot, P Henry, S Herson, B Hoen, P Houriez, L Hustache-Mathieu, O Huttin, S Imbert, B Iung, S Jaureguiberry, M Kaaki, A Konate, J M Kuhn, S Kural Menasche, A Lafitte, B Lafon, F Lanternier, V Le Chenault, V Le Moing, C Lechiche, S Lefèvre-Thibaut, A Lefort, A Leguerrier, J Lemoine, L Lepage, C Leport, C Lepousé, J Leroy, P Lesprit, L Letranchant, D Loisance, G Loncar, C Lorentz, P Mabo, I Magnin-Poull, T May, A Makinson, H Man, M Mansouri, O Marcxon, J P Maroni, V Masse, F Maurier, M C Meyohas, P L Michel, C Michelet, F Mechaï, O Merceron, D Messika-Zeitoun, Z Metref, V Meyssonnier, C Mezher, S Micheli, M Monsigny, S Mouly, B Mourvillier, O Nallet, P Nataf, P Nazeyrollas, V Noel, J F Obadia, E Oziol, T Papo, B Payet, A Pelletier, P Perez, J S Petit, F Philippart, E Piet, C Plainvert, B Popovic, J M Porte, P Pradier, R Ramadan, M Revest, J Richemond, M Rodermann, M Roncato, I Roigt, O Ruyer, M Saada, J Schwartz, C Selton-Suty, M Simon, B Simorre, S Skalli, F Spatz, C Strady, J Sudrial, L Tartiere, A Terrier De La Chaise, M C Thiercelin, D Thomas, M Thomas, L Toko, F Tournoux, A Tristan, J L Trouillet, L Tual, A Vahanian, F Verdier, V Vernet Garnier, V Vidal, P Weyne, M Wolff, A Wynckel, N Zannad, P Y Zinzius

Affiliations

¹ Maladies Infectieuses et Reanimation Médicale, Inserm CIC 1414, Hôpital Pontchaillou, Centre Hospitalo-Universitaire, Université Rennes 1, Rennes, France.
² UF Urgences Microbiologiques et Mycobactériologie, Département des Agents Infectieux, DMU BioGem APHP-Nord, Hôpital Lariboisière, Université de Paris, Inserm UMR 1137 IAME, Paris, France.
³ Inserm, Centre Hospitalier Régional Universitaire, Université de Lorraine, CIC-1433 Epidemiologie Clinique, Nancy, France.
⁴ Microbiologie, Hôpital Pontchaillou, Centre Hospitalo-Universitaire, Rennes, France.
⁵ Maladies Infectieuses et Tropicales, Centre Hospitalier Régional Universitaire, Université de Lorraine, Nancy, France.
⁶ Bactériologie, Centre Hospitalier Régional Universitaire, Hôpital Jean Minjoz, Besançon, France.
⁷ Microbiologie, Centre Hospitalier Universitaire, Reims, France.
⁸ Maladies Infectieuses et Tropicales, Centre Hospitalo-Universitaire, Université de Montpellier, Montpellier, France.
⁹ Inserm CIC 1425, AP-HP Nord, Hôpital Bichat, Inserm UMR-1137, IAME, Centre Hospitalo-Universitaire, Université de Paris, UFR de Médecine-Bichat, Paris, France.

PMID: 32420404
PMCID: PMC7216922
DOI: 10.1093/ofid/ofaa127

Abstract

Background: Increased access to heart valves through early surgery and progress in molecular microbiology have reduced the proportion of infective endocarditis (IE) with no microbiological documentation and increased the proportion of IE associated with unusual microorganisms.

Methods: We performed an ancillary study of a large prospective population-based survey on IE. Unusual-microorganism IE was defined as definite IE (Duke-Li criteria) due to microorganisms other than streptococci, staphylococci, or enterococci.

Results: Of 471 cases of documented IE, 46 (9.8%) were due to unusal microorganisms; the following were involved in >1 case: Candida albicans (n = 4), Cutibacterium acnes (n = 4), Pseudomonas aeruginosa (n = 3), Cardiobacterium hominis (n = 3), and Coxiella burnetii (n = 2). Cases were documented with blood cultures (n = 37, 80.4%), heart valve polymerase chain reaction (PCR; n = 5), heart valve culture (n = 2), PCR on vertebral biopsy (n = 1), or serology (n = 1). As compared with IE due to staphylococci, streptococci, or enterococci (n = 420), IE due to unusual microorganisms occurred more frequently in patients with previously known heart disease (69.0% vs 44.3%; P = .002), prosthetic valve (40.5% vs 18.1%; P = .0006), longer duration of fever (mean, 35.1 ± 46.8 days vs 12.5 ± 17.8; P = .003), and who were more often nosocomial (38.1% vs 20.2%; P = .02).

Conclusions: In this population-based study, 9.8% of IE cases were due to unusual microorganisms, with a predominance of anaerobes, yeast, and gram-negative bacilli. As compared with IE related to staphylococci, streptococci, or enterococci, IE cases related to unusual microorganisms were associated with previously known heart disease, prosthetic valve, longer duration of fever, and nosocomial acquisition.

Trial registration: ORCID 0000-0003-3617-5411.

Keywords: Candida sp; Cutibacterium acnes; HACEK; Pseudomonas aeruginosa; endocarditis.

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References

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Infective Endocarditis Related to Unusual Microorganisms: A Prospective Population-Based Study

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Infective Endocarditis Related to Unusual Microorganisms: A Prospective Population-Based Study

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