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Clinical Trial
. 2020 Jul;190(1):33-36.
doi: 10.1111/bjh.16847. Epub 2020 Jun 2.

Temporal changes in immune blood cell parameters in COVID-19 infection and recovery from severe infection

Christina Y C Yip  1 , Eng Soo Yap  1   2   3 , Sanjay De Mel  2 , Winnie Z Y Teo  2   4 , Chun-Tsu Lee  2   4 , Sheryl Kan  3 , Melvin C C Lee  5 , Will N H Loh  5 , Er Luen Lim  6 , Shir Ying Lee  1   2
Affiliations
Clinical Trial

Temporal changes in immune blood cell parameters in COVID-19 infection and recovery from severe infection

Christina Y C Yip et al. Br J Haematol. 2020 Jul.
No abstract available

Keywords: COVID-19; antibody-synthesising lymphocytes; disease; full blood count; lymphocytes; severity.

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Conflict of interest statement

All authors declare no competing interests.

Figures

Fig 1
Fig 1
Time trend of haematological parameters in patients with confirmed COVID‐19 with severe and critical illness. (A) White blood cell and neutrophil count (left axis), platelet count (right axis) decreased to its nadir level at day 8–9, but increased to normal ranges thereafter. (B) Absolute count of lymphocytes, reactive lymphocytes (RE‐Lymph) and its subset antibody‐synthesising lymphocytes (AS‐Lymph) increased progressively up to day 16. (C) Relative percentage of RE‐Lymph and AS‐Lymph (right axis) were trended with the absolute lymphocyte count across the day of illness.
See this image and copyright information in PMC

References

    1. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395:497–506. - PMC - PubMed
    1. Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID‐19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA. 2020;323:1239–42. - PubMed
    1. Sysmex Europe GmbH . Novel haematological parameters for rapidly monitoring the immune system response. Sysmex White Paper Infection/Inflammation. In: Sysmex white paper Infection/inflammation. 2017, pp. 1–5.
    1. Linssen J, Jennissen V, Hildmann J, Reisinger E, Schindler J, Malchau G, et al. Identification and quantification of high fluorescence‐stained lymphocytes as antibody synthesizing/secreting cells using the automated routine hematology analyzer XE‐2100. Cytometry B Clin Cytom. 2007;72:157–66. - PubMed
    1. Shi Y, Wang Y, Shao C, Huang J, Gan J, Huang X, et al. COVID‐19 infection: the perspectives on immune responses. Cell Death Differ. 2020;27:1451–4. - PMC - PubMed