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Comment
. 2020 May 11;4(5):95-98.
doi: 10.15698/cst2020.05.219.

HIF1α or mitophagy: which drives cardiomyocyte differentiation?

Beatriz Villarejo-Zori  1   2 , Juan Ignacio Jiménez-Loygorri  1   2 , Patricia Boya  1
Affiliations
Comment

HIF1α or mitophagy: which drives cardiomyocyte differentiation?

Beatriz Villarejo-Zori et al. Cell Stress. .
No abstract available

Keywords: HIFα; NIX; cardiomyocyte; differentiation; glycolisis; mitophagy.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest: No conflict of interest to disclose.

Figures

Figure 1
Figure 1. FIGURE 1: NIX accelerates cardiomyocyte differentiation.
Upregulation of HIF1α activity in response to a variety of stimuli, including hypoxia and developmental signalling, modulates the bioenergetic status of the cell by triggering receptor-mediated mitophagy. These changes allow for the increase in cellular glycolytic capacity necessary to provide energy to drive cardiomyocyte differentiation. Zhao et al. demonstrate that this process is dependent on HIF1α but not on NIX. However, NIX overexpression accelerates the glycolytic shift and leads to early differentiation as evidenced by increased levels of the cardiomyocyte markers MHC and troponin T.
See this image and copyright information in PMC

Comment on

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