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Observational Study
. 2020 Jun 23;50(4):1007-1014.
doi: 10.3906/sag-2002-61.

Prospective evaluation of vascular changes in acute respiratory infections in children with cystic fibrosis

Gökçen Kartal Öztürk  1 , Aykut Eşki  1 , Figen Çelebi Çelik  1 , Seçil Conkar  2 , Figen Gülen  1 , Esen Demir  1 , Ahmet Keskinoğlu  2
Affiliations
Observational Study

Prospective evaluation of vascular changes in acute respiratory infections in children with cystic fibrosis

Gökçen Kartal Öztürk et al. Turk J Med Sci. .

Abstract

Background/aim: Acute exacerbations and chronic inflammation are risk factors for cardiovascular disease (CVD) in cystic fibrosis (CF) patients. The aim of this study was to investigate the effects of acute exacerbation therapy on arterial stiffness in children with CF.

Materials and methods: Augmentation index (Aix) and pulse wave velocity (PWV) were measured before and after treatment and 1 month after the end of treatment in patients with acute exacerbation. The relationship between hemodynamic measurements and c-reactive protein (CRP) and pulmonary function tests (PFTs) was investigated.

Results: Measurements before and after treatment were evaluated in 27 patients and were repeated in 21 patients who were clinically stable 1 month following acute exacerbation. There was a significant decrease in CRP and an increase in spirometry parameters after treatment. While no significant difference was found between PWV (P = 0.33), a significant difference for Aix before (41.95 ± 12.96%) and after (30.95 ± 11.47%) treatment and before treatment and stable clinical condition (34.19 ± 14.36%) was obtained (P =0.00, and P =0.01, respectively). No significant difference in heart rate and other hemodynamic measurements was found. Pretreatment Aix is associated with poor clinical condition (PFTs, BMI, and clinical score) and systemic inflammation (CRP) (P <0.05).

Conclusion: The decrease of arterial stiffness (Aix) with acute exacerbation treatment in children with CF has been demonstrated. This result shows that systemic inflammation in CF may cause an increase in arterial stiffness and recurrent exacerbations may increase the risk of CVD.

Keywords: Cystic fibrosis; arterial stiffness; augmentation index; pulmonary exacerbation; pulse wave velocity analysis; augmentation index; pulmonary exacerbation.

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Conflict of interest statement

The authors declare that there is no conflict of interest.

Figures

Figure
Figure
Augmentation index (Aix, %) before treatment, after treatment, and in clinically stable period.
See this image and copyright information in PMC

References

    1. Mills NL Miller JJ Anand A Robinson SD Frazer GA Increased arterial stiffness in patients with chronic obstructive pulmonary disease: a mechanism for increased cardiovascular risk. Thorax. 2008;63:306. - PubMed
    1. Roman MJ Devereux RB Schwartz JE Lockshin MD Paget SA Arterial stiffness in chronic inflammatory diseases. Hypertension. 2005;46:194. - PubMed
    1. Schillaci G De Socio GV Pucci G Mannarino MR Helou J Aortic stiffness in untreated adult patients with human immunodeficiency virus infection. Hypertension. 2008;52:308. - PubMed
    1. Hull JH Garrod R Ho TB Knight RK Cockcroft JR Increased augmentation index in patients with cystic fibrosis. The European Respiratory Journal. 2009;34:1322. - PubMed
    1. Urbina EM Williams RV Alpert BS Collins BT Daniels RN Noninvasive assessment of subclinical atherosclerosis in children and adolescents: recommendations for standard assessment for clinical research: a scientific statement from the American Heart Association. 2009;54:919. - PubMed

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