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Editorial
. 2020 Sep;15(9):987-992.
doi: 10.1080/17460441.2020.1765770. Epub 2020 May 18.

Challenges identifying efficacious miRNA therapeutics for cancer

Meirav Segal  1 , Frank J Slack  1
Affiliations
Editorial

Challenges identifying efficacious miRNA therapeutics for cancer

Meirav Segal et al. Expert Opin Drug Discov. 2020 Sep.
No abstract available

Keywords: Microrna; delivery; miRNA; nanoparticle; oligonucleotide; oncogene; tumor suppressor.

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Conflict of interest statement

Declaration of Interest:

F Slack discloses financial interests and Scientific Advisory Board roles with Mira DX and MiRNA Therapeutics. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

Figures

Figure 1.
Figure 1.. Modification of nucleic acids.
O-MOE is O-(2-Methoxyethyl); OMe is O-Methyl; LNA is locked nucleic acid; F is Fluoro
See this image and copyright information in PMC

References

    1. Hayes J, Peruzzi PP, Lawler S. MicroRNAs in cancer: biomarkers, functions and therapy. Trends Mol Med. 2014;20(8):460–469. - PubMed

    2. ** Excellent general review on the topic

    1. Li Y, Kowdley KV. MicroRNAs in Common Human Diseases. Genomics, Proteomics & Bioinformatics. 2012;10(5):246–253. - PMC - PubMed
    1. Gilles M-E, Hao L, Huang L, et al. Personalized RNA-medicine for pancreatic cancer. Clinical Cancer Research. 2018. - PubMed

    2. ** The first report of using personalized RNAseq and avatars to point to the most effective microRNA-based therapeutics

    1. Kasinski AL, Kelnar K, Stahlhut C, et al. A combinatorial microRNA therapeutics approach to suppressing non-small cell lung cancer. Oncogene. 2015;34(27):3547–3555. - PMC - PubMed
    1. Zhang B, Pan X, Cobb GP, et al. microRNAs as oncogenes and tumor suppressors. Developmental Biology. 2007;302(1):1–12. - PubMed

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