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Review
. 2019;24(3):285-305.
doi: 10.1615/CritRevOncog.2019032959.

Obesity, Type-2 Diabetes and Cancer: Mechanistic Insights

Khosrow Kashfi  1 , Casey L Rosen  2 , Melissa Aslan  3
Affiliations
Review

Obesity, Type-2 Diabetes and Cancer: Mechanistic Insights

Khosrow Kashfi et al. Crit Rev Oncog. 2019.

Abstract

Obesity leads to many diseases including hypercholesterolemia, type-2 diabetes, hypertension, cardiovascular disease, and cancer. It is the fastest-growing lethal disease in the Western and developing countries. The link between obesity and cancer is relatively underappreciated among the general population. Obesity represents the number one risk factor for type-2 diabetes and a considerable body of epidemiological studies supports the relationship between type-2 diabetes and many cancers. In this review, we examine the obesity-type-2-diabetes-cancer relationships from a mechanistic perspective, and where appropriate, we highlight potential pharmaceutical and dietary interventions.

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Figures

FIG. 1:
FIG. 1:
Process of white adipose tissue (WAT) inflammation as described in Iyengar et al.
FIG. 2:
FIG. 2:
Schematic diagram of the biochemical features of obesity. Reprinted from Martinez-Useros and Garcia-Foncillas, with permission from Springer, Copyright 2016.
FIG. 3:
FIG. 3:
Putative mechanisms linking obesity with cancer risk and progression: lessons from studies of chemopreventive agents. Reprinted from Allott and Hursting, with permission from Bioscientifica Limited.
See this image and copyright information in PMC

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