COVID-19 and Angiotensin-Converting Enzyme Inhibitor/Angiotensin-Receptor Blocker Therapy
- PMID: 32422077
- PMCID: PMC7249506
- DOI: 10.7326/M20-3047
COVID-19 and Angiotensin-Converting Enzyme Inhibitor/Angiotensin-Receptor Blocker Therapy
Abstract
Mackey and colleagues reported a systematic review that found high-certainty evidence that angiotensin-converting enzyme inhibitors and angiotensin-receptor blockers are not associated with greater illness severity in patients with COVID-19. The editorialist discusses the findings and emphasizes that, unless further data show otherwise, clinicians should continue to prescribe these drugs for their standard indications in patients with COVID-19.
Comment on
-
Risks and Impact of Angiotensin-Converting Enzyme Inhibitors or Angiotensin-Receptor Blockers on SARS-CoV-2 Infection in Adults: A Living Systematic Review.Ann Intern Med. 2020 Aug 4;173(3):195-203. doi: 10.7326/M20-1515. Epub 2020 May 15. Ann Intern Med. 2020. Update in: Ann Intern Med. 2021 Feb;174(2):W25-W29. doi: 10.7326/L20-1446. Update in: Ann Intern Med. 2021 Jun;174(6):W54-W55. doi: 10.7326/L21-0223. PMID: 32422062 Free PMC article. Updated.
References
-
- Esler M, Esler D. Can angiotensin receptor-blocking drugs perhaps be harmful in the COVID-19 pandemic? J Hypertens. 2020;38:781-2. [PMID: 32195824] doi:10.1097/HJH.0000000000002450. - PubMed
-
- Pflugfelder PW, Baird MG, Tonkon MJ, et al. Clinical consequences of angiotensin-converting enzyme inhibitor withdrawal in chronic heart failure: a double-blind, placebo-controlled study of quinapril. The Quinapril Heart Failure Trial Investigators. J Am Coll Cardiol. 1993;22:1557-63. [PMID: 8227822] - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources