Competing interests: FB reports personal fees from Boehringer, Bone Therapeutics, Expanscience, Galápagos, Gilead, GSK, Lilly, Merck Serono, MSD, Nordic, Novartis, Pfizer, Regulaxis, Roche, Sandoz, Sanofi, Servier, UCB, Peptinov, TRB Chemedica, 4P Pharma, outside the submitted work. FJB reports grants and personal fees from Pfizer, and grants from AbbVie, UCB, Bristol-Myers Squibb, Roche, Servier, Bioiberica, Sanofi, Grünenthal, GlaxoSmithKline, Lilly, Janssen, Regeneron, Amgen, and TRB Chemedica, outside the submitted work. AG reports personal fees from MerckSerono, Pfizer, TissueGene, Roche, Galápagos, AstraZeneca, and personal fees from Boston Imaging Core Lab, outside the submitted work. KM reports personal fees from Merck, Pfizer, Lilly, Ayumi, Mundipharma, Janssen, and Nippon Zoki, outside the submitted work. TY reports personal fees and other from Pfizer, outside the submitted work. LV reports personal fees and other from Eli Lilly and Company, outside the submitted work. RJ reports personal fees and other from Pfizer, outside the submitted work. WC reports personal fees and other from Pfizer, outside the submitted work. MTB reports personal fees and other from Pfizer, outside the submitted work. CRW reports personal fees and other from Pfizer, outside the submitted work. KMV reports personal fees and other from Pfizer, outside the submitted work.