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. 2020 Jul 1;35(7):1499-1504.
doi: 10.1093/humrep/deaa050.

Choice of statistical model in observational studies of ART

Laura E Dodge  1   2   3 , Leslie V Farland  4 , Katharine F B Correia  5 , Stacey A Missmer  3   6 , Emily A Seidler  1   2   7 , Jack Wilkinson  8 , Anna M Modest  1   2 , Michele R Hacker  1   2   3
Affiliations

Choice of statistical model in observational studies of ART

Laura E Dodge et al. Hum Reprod. .

Abstract

Analyzing data on ART presents unique and sometimes complicated challenges related to choosing the unit(s) of analysis and the statistical model. In this commentary, we provide examples of how these challenges arise and guidance for overcoming them. We discuss the implications of different ways to count treatment cycles, considering the perspectives of research questions, data management and analysis and patient counseling. We present the advantages and disadvantages of different statistical models, and finally, we discuss the definition and calculation of the cumulative incidence of live birth, which is a key outcome of research on ART.

Keywords: assisted reproductive technologies; data analysis; data reporting; research methods; statistical models.

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References

    1. Centers for Disease Control and Prevention. American Society for Reproductive Medicine, Society for Assisted Reproductive Technology In: 2016 Assisted Reproductive Technology National Summary Report. Atlanta (GA): US Dept of Health and Human Services, Washington, DC, USA, 2018.
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    1. Correia KFB, Dodge LE, Farland LV, Hacker MR, Ginsburg E, Whitcomb BW, Wise LA, Missmer SA. Confounding and effect measure modification in reproductive medicine. Hum Repro 2020. doi: 10.1093/humrep/deaa051. - DOI - PMC - PubMed
    1. Dodge LE, Missmer SA, Thornton KL, Hacker MR. Women’s alcohol consumption and cumulative incidence of live birth following in vitro fertilization. J Assist Reprod Genetics 2017;34:877–883. - PMC - PubMed
    1. Domar AD, Rooney K, Hacker MR, Sakkas D, Dodge LE. Burden of care is the primary reason why insured women terminate in vitro fertilization treatment. Fertil Steril 2018;109:1121–1126. - PMC - PubMed

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