A special symptom of olfactory dysfunction in coronavirus disease 2019: report of three cases

doi:10.1007/s13365-020-00849-w

Case Reports

. 2020 Jun;26(3):456-458.

doi: 10.1007/s13365-020-00849-w. Epub 2020 May 18.

A special symptom of olfactory dysfunction in coronavirus disease 2019: report of three cases

Chen Chen¹, Moxian Chen¹, Cong Cheng¹, Yun Chi¹, Zhiliang Hu¹, Yuan Liu¹, Shan Huang¹, Yanling Lv², Chongfeng Liang¹, Damin Jiao³, Yongxiang Yi⁴, Xia Zhang⁵, Wenkui Sun⁶, Hongxia Wei⁷

Affiliations

¹ Department of Infectious Disease, Nanjing Infectious Disease Center, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, #1-1 Zhongfu Road, Nanjing, 210003, Jiangsu, China.
² Department of Respiratory & Critical Care Medicine, Nanjing Infectious Disease Center, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
³ Department of Rheumatology and Immunology, Nanjing Infectious Disease Center, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
⁴ Department of Hepatobiliary Surgery, Nanjing Infectious Disease Center, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
⁵ Department of Tuberculosis, Nanjing Infectious Disease Center, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
⁶ Department of Respiratory & Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, #300 Guangzhou Road, Nanjing, 210029, Jiangsu, China. sunwenkui@njmu.edu.cn.
⁷ Department of Infectious Disease, Nanjing Infectious Disease Center, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, #1-1 Zhongfu Road, Nanjing, 210003, Jiangsu, China. wghongxia@sina.com.

PMID: 32424616
PMCID: PMC7234447
DOI: 10.1007/s13365-020-00849-w

Case Reports

A special symptom of olfactory dysfunction in coronavirus disease 2019: report of three cases

Chen Chen et al. J Neurovirol. 2020 Jun.

. 2020 Jun;26(3):456-458.

doi: 10.1007/s13365-020-00849-w. Epub 2020 May 18.

Authors

Affiliations

¹ Department of Infectious Disease, Nanjing Infectious Disease Center, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, #1-1 Zhongfu Road, Nanjing, 210003, Jiangsu, China.
² Department of Respiratory & Critical Care Medicine, Nanjing Infectious Disease Center, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
³ Department of Rheumatology and Immunology, Nanjing Infectious Disease Center, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
⁴ Department of Hepatobiliary Surgery, Nanjing Infectious Disease Center, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
⁵ Department of Tuberculosis, Nanjing Infectious Disease Center, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
⁶ Department of Respiratory & Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, #300 Guangzhou Road, Nanjing, 210029, Jiangsu, China. sunwenkui@njmu.edu.cn.
⁷ Department of Infectious Disease, Nanjing Infectious Disease Center, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, #1-1 Zhongfu Road, Nanjing, 210003, Jiangsu, China. wghongxia@sina.com.

PMID: 32424616
PMCID: PMC7234447
DOI: 10.1007/s13365-020-00849-w

Abstract

Three patients of coronavirus disease (COVID-19) showed the symptoms of olfactory dysfunction. Clinical characteristics and treatment were retrospective analyzed. Olfactory disorders are uncommon symptoms of COVID-19 in China. Early diagnosis and intervention are keys to the recovery of olfactory disorders. Particular attention should be devoted to olfactory dysfunction.

Keywords: COVID-19; Olfactory dysfunction.

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Conflict of interest statement

The authors declare that they have no conflict of interest. All authors meet the ICMJE authorship criteria.

Figures

**Fig. 1**
The course of symptoms and treatments

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References

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1. Lechien JR, Chiesa-Estomba CM, De Siati DR, Horoi M, Le Bon SD, Rodriguez A, Dequanter D, Blecic S, El Afia F, Distinguin L, Chekkoury-Idrissi Y, Hans S, Delgado IL, Calvo-Henriquez C, Lavigne P, Falanga C, Barillari MR, Cammaroto G, Khalife M, Leich P, Souchay C, Rossi C, Journe F, Hsieh J, Edjlali M, Carlier R, Ris L, Lovato A, De Filippis C, Coppee F, Fakhry N, Ayad T, Saussez S (2020). Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study. Eur Arch Otorhinolaryngol. 2020. doi: 10.1007/s00405-020-05965-1. Online ahead of print - PMC - PubMed
1. Schriever VA, Merkonidis C, Gupta N, Hummel C, Hummel T. Treatment of smell loss with systemic methylprednisolone. Rhinology. 2012;50:284–289. doi: 10.4193/Rhin11.207. - DOI - PubMed

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[1] Gralinski LE, Menachery VD. Return of the coronavirus: 2019-nCoV. Viruses. 2020;12:E135. doi: 10.3390/v12020135. - DOI - PMC - PubMed

[2] Gralinski LE, Menachery VD. Return of the coronavirus: 2019-nCoV. Viruses. 2020;12:E135. doi: 10.3390/v12020135. - DOI - PMC - PubMed

[3] Harless L, Liang J. Pharmacologic treatment for postviral olfactory dysfunction: a systematic review. Int Forum Allergy Rhinol. 2016;6:760–767. doi: 10.1002/alr.21727. - DOI - PubMed

[4] Harless L, Liang J. Pharmacologic treatment for postviral olfactory dysfunction: a systematic review. Int Forum Allergy Rhinol. 2016;6:760–767. doi: 10.1002/alr.21727. - DOI - PubMed

[5] Hwang CS. Olfactory neuropathy in severe acute respiratory syndrome: report of a case. Acta Neurol Taiwanica. 2006;15:26–28. - PubMed

[6] Hwang CS. Olfactory neuropathy in severe acute respiratory syndrome: report of a case. Acta Neurol Taiwanica. 2006;15:26–28. - PubMed

[7] Lechien JR, Chiesa-Estomba CM, De Siati DR, Horoi M, Le Bon SD, Rodriguez A, Dequanter D, Blecic S, El Afia F, Distinguin L, Chekkoury-Idrissi Y, Hans S, Delgado IL, Calvo-Henriquez C, Lavigne P, Falanga C, Barillari MR, Cammaroto G, Khalife M, Leich P, Souchay C, Rossi C, Journe F, Hsieh J, Edjlali M, Carlier R, Ris L, Lovato A, De Filippis C, Coppee F, Fakhry N, Ayad T, Saussez S (2020). Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study. Eur Arch Otorhinolaryngol. 2020. doi: 10.1007/s00405-020-05965-1. Online ahead of print - PMC - PubMed

[8] Lechien JR, Chiesa-Estomba CM, De Siati DR, Horoi M, Le Bon SD, Rodriguez A, Dequanter D, Blecic S, El Afia F, Distinguin L, Chekkoury-Idrissi Y, Hans S, Delgado IL, Calvo-Henriquez C, Lavigne P, Falanga C, Barillari MR, Cammaroto G, Khalife M, Leich P, Souchay C, Rossi C, Journe F, Hsieh J, Edjlali M, Carlier R, Ris L, Lovato A, De Filippis C, Coppee F, Fakhry N, Ayad T, Saussez S (2020). Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study. Eur Arch Otorhinolaryngol. 2020. doi: 10.1007/s00405-020-05965-1. Online ahead of print - PMC - PubMed

[9] Schriever VA, Merkonidis C, Gupta N, Hummel C, Hummel T. Treatment of smell loss with systemic methylprednisolone. Rhinology. 2012;50:284–289. doi: 10.4193/Rhin11.207. - DOI - PubMed

[10] Schriever VA, Merkonidis C, Gupta N, Hummel C, Hummel T. Treatment of smell loss with systemic methylprednisolone. Rhinology. 2012;50:284–289. doi: 10.4193/Rhin11.207. - DOI - PubMed

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A special symptom of olfactory dysfunction in coronavirus disease 2019: report of three cases

Affiliations

A special symptom of olfactory dysfunction in coronavirus disease 2019: report of three cases

Authors

Affiliations

Abstract

Conflict of interest statement

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References

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Medical

Abstract

Conflict of interest statement

Figures

Similar articles

Cited by

References

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Medical