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Using Mt. Sinai (New York City) EMR health system data, we retrospectively analyzed a cohort of 8438 COVID-19 patients seen between March 1 and April 22, 2020. Risk of intubation and of death rose as a function of increasing age and as a function of greater cardiovascular comorbidity. Combining age and specific comorbidity markers showed patterns suggesting that cardiovascular comorbidities increased relative risks for adverse outcomes most substantially in the younger subjects with progressively diminishing relative effects at older ages.
Zhu N., Zhang D., Wang W. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020;382:727–733.
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Coronavirus COVID-19 Global Cases by the Center for Systems Science and Enginerring at Johns Hopkins University. https://coronavirus.jhu.edu/map.html
Shi S., Qin M., Shen B. China; JAMA Cardiol: 2020. Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan.
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Yang J., Zheng Y., Gou X. Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and meta-analysis. Int J Infect Dis. 2020;94:91–95. doi: 10.1016/j.ijid.2020.03.017.
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Miyashita H, Mikami T, Chopra N, Yamada T, Chernyavsky S, Rizk D, Cruz C. Do patients with Cancer Have a Poorer Prognosis of COVID-19? An Experience in New York City. Annals of Oncology In Press 10.1016/j.annonc.2020.04.006
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