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. 2020 Jul:96:531-537.
doi: 10.1016/j.ijid.2020.05.045. Epub 2020 May 17.

Factors associated with the duration of viral shedding in adults with COVID-19 outside of Wuhan, China: a retrospective cohort study

Lin Qi  1 , Yong Yang  2 , Dixuan Jiang  3 , Chao Tu  1 , Lu Wan  4 , Xiangyu Chen  5 , Zhihong Li  1
Affiliations

Factors associated with the duration of viral shedding in adults with COVID-19 outside of Wuhan, China: a retrospective cohort study

Lin Qi et al. Int J Infect Dis. 2020 Jul.

Abstract

Objectives: To investigate factors associated with the duration of viral shedding in patients with COVID-19, outside of Wuhan.

Methods: In this retrospective cohort study, patients with laboratory-confirmed COVID-19 in Changsha, China were included. Clinical characteristics, laboratory findings, treatment, and outcome were retrieved. Univariate and multivariate analyses were performed to explore potential factors.

Results: Overall, 147 patients with COVID-19 were included. The median duration of viral shedding (the number of days from symptoms onset until the successive negative detection of SARS-CoV-2 RNA) was 17 days (interquartile range [IQR], 12-21). Multivariate Logistic regression analysis indicated that the highest temperature at admission (odds ratio [OR], 5.200; 95% confidence interval [CI]: 1.190-22.726; p = 0.028), time from symptom onset to admission (OR, 1.740; 95% CI: 1.296-2.337; p < 0.001) and hospital length of stay (OR, 1.604; 95% CI: 1.262-2.040; p < 0.001) were risk factors for prolonged duration of viral shedding.

Conclusions: This study, with a relatively large sample size, focused on the duration of viral shedding and related factors in patients with COVID-19, outside of Wuhan, China. Potential risk factors were identified and should be taken into consideration for the strategy of quarantining infected patients.

Keywords: 2019 novel coronavirus disease (COVID-19); Changsha; Risk factor; Viral shedding.

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Figures

Figure 1
Figure 1
Dynamics of the viral load in patients with a duration of viral shedding less than 17 days (n = 30) (A) and patients with a duration of more than 17 days (n = 31) (B).
Figure 2
Figure 2
ROC curve of the final multivariate logistic regression model (AUC = 0.935, 95%CI: 0.861-0.977).
See this image and copyright information in PMC

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