Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 May 6;6(2):120-123.
doi: 10.2478/jccm-2020-0014. eCollection 2020 Apr.

The Use of Extracorporeal Life Support in a Patient Suffering from Venlafaxine Intoxication. A Case Report

Christoph Marquetand  1 , Harald F Langer  1 , Jan Philipp Klein  2 , Tobias Graf  1
Affiliations

The Use of Extracorporeal Life Support in a Patient Suffering from Venlafaxine Intoxication. A Case Report

Christoph Marquetand et al. J Crit Care Med (Targu Mures). .

Abstract

Very few reports exist on serious cardiac complications associated with intake of serotonin-noradrenaline reuptake inhibitors. This paper describes and discusses the case of a patient who ingested a dose of 17.5 g venlafaxine. She developed a full serotonergic syndrome leading to multi-organ failure, including refractory cardiovascular shock, which was managed by early implantation of an extracorporeal life support (ECLS) system as a bridging strategy. This intervention was successful and resulted in full recovery of the patient.

Keywords: ECLS; ECMO; cardiogenic shock; intoxication; venlafaxine.

PubMed Disclaimer

References

    1. Cipriani A, Furukawa TA, Salanti G, Chaimani A, Atkinson LZ, Ogawa Y. Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis. Lancet. 2018;391:1357–66. et al. - PMC - PubMed
    1. Schroeder I, Zoller M, Angstwurm M, Kur F, Frey L. Venlafaxine intoxication with development of takotsubo cardiomyopathy: Successful use of extracorporeal life support, intravenous lipid emulsion and CytoSorb®. Int J Artif Organs. 2017;40:358–60. - PubMed
    1. Mazur JE, Doty JD, Krygiel AS. Fatality Related to a 30-g Venlafaxine Overdose. Pharmacotherapy. 2003;23:1668–72. - PubMed
    1. Thomas A, Ovakim D, Kanji H, Dewar L, Finlayson G. Intravenous Lipid Emulsion Therapy and VA-ECMO rescue therapy for Massive Venlafaxine and Clonazepam Overdose. J Clin Toxicol. 2017;07
    1. Vasudev R, Rampal U, Patel H, Patel K, Bikkina M, Shamoon F. Selective Serotonin-norepinephrine Reuptake Inhibitors-induced Takotsubo Cardiomyopathy. N Am J Med Sci. 2016;8:312–5. - PMC - PubMed

LinkOut - more resources