The diagnostic, prognostic and therapeutic potential of circulating microRNAs in ovarian cancer

Affiliations

¹ Department of Anatomy, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
² Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran.
³ Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
⁴ Student Research Committee, Islamic Azad University, Mashhad Branch, Mashhad, Iran.
⁵ Iranshahr University of Medical Sciences, Iranshahr, Iran.
⁶ Department of Medical Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
⁷ Department of Biochemistry, Payame-Noor University, Mashhad, Iran.
⁸ College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
⁹ Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, UK.
¹⁰ Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
¹¹ Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, UK. Electronic address: hasanianmehrm@mums.ac.ir.

PMID: 32428568
DOI: 10.1016/j.biocel.2020.105765

Review

The diagnostic, prognostic and therapeutic potential of circulating microRNAs in ovarian cancer

Hamideh Aboutalebi et al. Int J Biochem Cell Biol. 2020 Jul.

. 2020 Jul:124:105765.

doi: 10.1016/j.biocel.2020.105765. Epub 2020 May 17.

Authors

Affiliations

¹ Department of Anatomy, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
² Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran.
³ Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
⁴ Student Research Committee, Islamic Azad University, Mashhad Branch, Mashhad, Iran.
⁵ Iranshahr University of Medical Sciences, Iranshahr, Iran.
⁶ Department of Medical Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
⁷ Department of Biochemistry, Payame-Noor University, Mashhad, Iran.
⁸ College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
⁹ Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, UK.
¹⁰ Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
¹¹ Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, UK. Electronic address: hasanianmehrm@mums.ac.ir.

PMID: 32428568
DOI: 10.1016/j.biocel.2020.105765

Abstract

Ovarian cancer (OC) is often diagnosed at an advanced stage because of the late onset of symptoms, and this together with the lack of effective treatments, has meant it is associated with a very high mortality. The aberrant expression of MicroRNA (miRNA) contributes to the initiation and development of human tumors including OC. Several miRNAs are secreted by tumor cells and can be identified in body fluids. Serum miRNAs levels are associated with several clinical conditions, and may be used to predict prognosis and response to treatments in some cancers including OC. This review summarizes the current progresses regarding the potential applications of circulating miRNA as innovative biomarkers in OC.

Keywords: Biomarker; Circulating microRNA; Extracellular microRNA; Ovarian cancer.

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Conflict of interest statement

Declaration of Competing Interest The authors have no financial conflicts of interest.

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The diagnostic, prognostic and therapeutic potential of circulating microRNAs in ovarian cancer

Affiliations

The diagnostic, prognostic and therapeutic potential of circulating microRNAs in ovarian cancer

Authors

Affiliations

Abstract

Conflict of interest statement

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Medical