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. 2020 Jul-Aug;14(4):637-639.
doi: 10.1016/j.dsx.2020.05.022. Epub 2020 May 12.

Angiotensin converting enzyme-2 as therapeutic target in COVID-19

Neda Roshanravan  1 , Samad Ghaffari  2 , Mehdi Hedayati  3
Affiliations

Angiotensin converting enzyme-2 as therapeutic target in COVID-19

Neda Roshanravan et al. Diabetes Metab Syndr. 2020 Jul-Aug.

Abstract

The pandemic of coronavirus disease 2019 (COVID-19) is a global health emergency that poses a significant threat to world people's health. This outbreak causes major challenges to healthcare systems. Given the lack of effective treatments or vaccine for it, the identification of novel and safe drugs against COVID-19 infection is an urgent need. Angiotensin-converting enzyme 2 (ACE2) is not only an entry receptor of the SARS-CoV-2 virus, the virus that causes COVID-19, but also can protect from lung injury. In this view, we highlighted potential approaches to address ACE2-mediated SARS-CoV-2 virus, including 1) delivering an excessive soluble form of ACE2 (recombinant human ACE2: rhACE2) and 2) inhibition of the interaction between SARS-CoV-2 virus and ACE2 by some compounds with competitive effects (morphine and codeine). Further clinical trials in this regard can reveal a more definite conclusion against the COVID-19 disaster.

Keywords: ACE2; COVID-19; Codeine; Morphine; SARS-CoV-2; rhACE2.

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Conflict of interest statement

Declaration of competing interest No potential conflict of interest disclosed.

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