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Review
. 2020 May 16;21(10):3536.
doi: 10.3390/ijms21103536.

Vitamin D and Cardiovascular Risk: which Implications in Children?

Silvia Savastio  1 , Erica Pozzi  1 , Francesco Tagliaferri  1 , Roberta Degrandi  1 , Roberta Cinquatti  1 , Ivana Rabbone  1   2 , Gianni Bona  1   2
Affiliations
Review

Vitamin D and Cardiovascular Risk: which Implications in Children?

Silvia Savastio et al. Int J Mol Sci. .

Abstract

Vitamin D (25OHD) pleiotropic effects are widely recognized and studied. Recently, vitamin D cardiovascular effects are gaining interest, especially in children, although the studies present conflicting data. Some randomized controlled trials (RCTs) have demonstrated that cardiovascular risk markers, such as lipid parameters, inflammation markers, blood pressure, and arterial stiffness, are unaffected by vitamin D supplementation. By contrast, other studies show that low vitamin D levels are associated with higher risk of cardiovascular disease (CVD) and mortality, and support that increased risk of these diseases occurs primarily in people with vitamin D deficiency. An update on these points in pediatric patients is certainly of interest to focus on possible benefits of its supplementation.

Keywords: cardiovascular risk; childhood; extra-skeletal effects; vitamin D.

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Conflict of interest statement

All the authors approved the final version of the manuscript that has not been previously published anywhere and has not been under consideration in any other journal. All the authors report no conflicts of interest.

Figures

Figure 1
Figure 1
The main mechanisms involved in cardiovascular risk due to vitamin D deficiency.
See this image and copyright information in PMC

References

    1. Al-Ishaq R.K., Kubatka P., Brozmanova M., Gazdikova K., Caprnda M., Büsselberg D. Health implication of vitamin D on the cardiovascular and the renal system. Arch. Physiol. Biochem. 2019:1–15. doi: 10.1080/13813455.2019.1628064. - DOI - PubMed
    1. Chen S., Swier V.J., Boosani C.S., Radwan M.M., Agrawal D.K. Vitamin D Deficiency Accelerates Coronary Artery Disease Progression in Swine. Arterioscler. Thromb. Vasc. Biol. 2016;36:1651–1659. doi: 10.1161/ATVBAHA.116.307586. - DOI - PMC - PubMed
    1. Sirajudeen S., Shah I., Al Menhali A. A narrative role of vitamin d and its receptor: With current evidence on the gastric tissues. Int. J. Mol. Sci. 2019;20:3832. doi: 10.3390/ijms20153832. - DOI - PMC - PubMed
    1. Bikle D. Vitamin D: Production, Metabolism, and Mechanisms of Action. MDText.com, Inc.; South Dartmouth, MA, USA: 2000.
    1. Tripkovic L., Lambert H., Hart K., Smith C.P., Bucca G., Penson S., Chope G., Hypponen E., Berry J., Vieth R., et al. Comparison of vitamin D2and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: A systematic review and meta-analysis. Am. J. Clin. Nutr. 2012;95:1357–1364. doi: 10.3945/ajcn.111.031070. - DOI - PMC - PubMed

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