Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 May 19;20(1):713.
doi: 10.1186/s12889-020-08850-y.

Compliance with the guidelines on recommended immunization schedule in patients with inflammatory bowel disease: implications on public health policies

Cristina García-Serrano  1   2 , Glòria Mirada  3   4 , Josep R Marsal  5 , Marta Ortega  1   6   7   8 , Joaquim Sol  9   10   11 , Rubén Solano  6 , Eva M Artigues  1   3   6   8   12 , Pepi Estany  1
Affiliations

Compliance with the guidelines on recommended immunization schedule in patients with inflammatory bowel disease: implications on public health policies

Cristina García-Serrano et al. BMC Public Health. .

Abstract

Background: Patients with inflammatory bowel disease (IBD) have a higher risk of developing opportunistic infections due to either the disease itself or to treatment with immunosuppressants. This risk can be reduced through vaccination. The aim of this study was to determine the prevalence of compliance with the guidelines on recommended immunization schedule in patients with IBD in the health district of Lleida, Spain.

Methods: Descriptive, cross-sectional, retrospective study of data at December 31, 2016. The reference population was formed by adults with a clinical diagnosis of IBD. The dependent variable was "compliance with the guidelines on recommended immunization schedule". Variables were sex, age, residence, diagnosis, vaccination against measles, mumps, rubella, varicella, tetanus-diphtheria, influenza, pneumococcus, meningococcus C, hepatitis B, and hepatitis A. Data were obtained from electronic medical records. For the data analysis, mean (standard deviation), prevalence with 95% confidence intervals, χ2 test and Mann-Whitney test were used.

Results: Compliance did not exceed 65% for any of vaccines analysed in the 1722 studied patients with ulcerative colitis or Crohn's disease. Significant differences across age groups were found in compliance for measles, mumps, rubella, varicella, tetanus, diphtheria and influenza in both ulcerative colitis and Crohn's disease and for meningococcus C and hepatitis A exclusively in ulcerative colitis.

Conclusions: Compliance in patients with IBD is low. Thus, prevention of immunopreventable diseases or their complications is not maximized in this kind of patients. Greater awareness of how vaccines can reduce the risk of vaccine-preventable infections is needed among both patients and healthcare professionals.

Keywords: Epidemiology; Immunization schedule; Inflammatory bowel disease; Public health.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Riestra Menéndez S, de Francisco García R, Pérez-Martínez I. Manejo extra-hospitalario de la enfermedad inflamatoria intestinal: papel de Atención Primaria. Med - Programa Form Médica Contin Acreditado. 2012;11(5):293–300. doi: 10.1016/S0304-5412(12)70301-3. - DOI
    1. Burisch J, Jess T, Martinato M, Lakatos PL, ECCO -EpiCom The burden of inflammatory bowel disease in Europe. J Crohns Colitis. 2013;7(4):322–337. doi: 10.1016/j.crohns.2013.01.010. - DOI - PubMed
    1. Ananthakrishnan AN. Epidemiology and risk factors for IBD. Nat Rev Gastroenterol Hepatol. 2015;12:205–217. doi: 10.1038/nrgastro.2015.34. - DOI - PubMed
    1. Panaccione R, Underwood FE, Ghosh S, Kaplan GG, Hamidi N, Benchimol EI, et al. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Lancet. 2017;390(10114):2769–2778. doi: 10.1016/S0140-6736(17)32448-0. - DOI - PubMed
    1. Vida Pérez L, Gómez Camacho F, García Sánchez V, Iglesias Flores EM, Castillo Molina L, Cerezo Ruiz A, et al. Eficacia de la vacuna contra el virus de la hepatitis B en pacientes con enfermedad inflamatoria intestinal. Med Clin (Barc) 2009;132(9):331–335. doi: 10.1016/j.medcli.2008.07.013. - DOI - PubMed

Publication types

MeSH terms