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Comment
. 2020 Aug 13;56(2):2001692.
doi: 10.1183/13993003.01692-2020. Print 2020 Aug.

Continuous positive airway pressure to avoid intubation in SARS-CoV-2 pneumonia: a two-period retrospective case-control study

Mathilde Oranger  1   2 , Jésus Gonzalez-Bermejo  1   3   2 , Philippine Dacosta-Noble  1 , Claudia Llontop  1 , Antoine Guerder  1 , Valery Trosini-Desert  1 , Morgane Faure  1 , Mathieu Raux  3   4 , Maxens Decavele  1 , Alexandre Demoule  1   3 , Capucine Morélot-Panzini  1   3   5 , Thomas Similowski  6   3   5
Affiliations
Comment

Continuous positive airway pressure to avoid intubation in SARS-CoV-2 pneumonia: a two-period retrospective case-control study

Mathilde Oranger et al. Eur Respir J. .

Abstract

COVID-19 pneumonia can be life-threatening. Given the unprecedented burden placed on ICU resources by the epidemic, avoiding intubation is a major issue. This study suggests that CPAP can achieve this objective. https://bit.ly/2X4Q8Zj

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Conflict of interest statement

Conflict of interest: M. Oranger has nothing to disclose. Conflict of interest: J. Gonzalez-Bermejo has nothing to disclose. Conflict of interest: P. Dacosta-Noble has nothing to disclose. Conflict of interest: C. Llontop has nothing to disclose. Conflict of interest: A. Guerder has nothing to disclose. Conflict of interest: V. Trosini-Desert has nothing to disclose. Conflict of interest: M. Faure has nothing to disclose. Conflict of interest: M. Raux has nothing to disclose. Conflict of interest: M. Decavele has nothing to disclose. Conflict of interest: A. Demoule has nothing to disclose. Conflict of interest: C. Morélot-Panzini reports personal fees for lectures from AstraZeneca, Menarini, SOS Oxygene and Resmed, personal fees for advisory board work and lectures from Chiesi and ADEP, personal fees for advisory board work from Vivisol, outside the submitted work. Conflict of interest: T. Similowski reports personal fees from AstraZeneca France, Boehringer Ingelheim France, GSK France, TEVA France, Chiesi France, Lungpacer Inc. and ADEP Assistance, personal fees and non-financial support from Novartis France, grants from Air Liquide Medical Systems, outside the submitted work.

Figures

FIGURE 1
FIGURE 1
a) Study flow chart. b) 7-day intubation-free survival. #: noninvasive ventilation (NIV) and alveolar hypoventilation defined as arterial carbon dioxide tension ≥45 mmHg; : five intubations and three deaths; two of the deaths occurred in the two “do not intubate” patients; +: there were six patients with “do not intubate” decisions, none of whom died (p=0.036 versus controls; Fisher's exact test). COVID-19: coronavirus disease 2019; CT: computed tomography; SpO2: peripheral oxygen saturation; CPAP: continuous positive airway pressure.
See this image and copyright information in PMC

Comment on

  • Clinical Characteristics of Coronavirus Disease 2019 in China.
    Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, Liu L, Shan H, Lei CL, Hui DSC, Du B, Li LJ, Zeng G, Yuen KY, Chen RC, Tang CL, Wang T, Chen PY, Xiang J, Li SY, Wang JL, Liang ZJ, Peng YX, Wei L, Liu Y, Hu YH, Peng P, Wang JM, Liu JY, Chen Z, Li G, Zheng ZJ, Qiu SQ, Luo J, Ye CJ, Zhu SY, Zhong NS; China Medical Treatment Expert Group for Covid-19. Guan WJ, et al. N Engl J Med. 2020 Apr 30;382(18):1708-1720. doi: 10.1056/NEJMoa2002032. Epub 2020 Feb 28. N Engl J Med. 2020. PMID: 32109013 Free PMC article.

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