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Observational Study
. 2020 Jul 30;56(1):2001157.
doi: 10.1183/13993003.01157-2020. Print 2020 Jul.

The liaison between respiratory failure and high blood pressure: evidence from COVID-19 patients

Marco Vicenzi  1   2 , Roberta Di Cosola  2 , Massimiliano Ruscica  3 , Angelo Ratti  2 , Irene Rota  4 , Federica Rota  5 , Valentina Bollati  5 , Stefano Aliberti  6   7 , Francesco Blasi  6   7
Affiliations
Observational Study

The liaison between respiratory failure and high blood pressure: evidence from COVID-19 patients

Marco Vicenzi et al. Eur Respir J. .

Abstract

In COVID-19 patients respiratory failure is associated with increased systemic blood pressure, conceivably due to the modulation of the renin-angiotensin-aldosterone system by SARS-CoV-2 infection https://bit.ly/3cINsHB

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Conflict of interest statement

Conflict of interest: M. Vicenzi reports personal fees from Janssen-Cilag SpA and MSD Italia, outside the submitted work. Conflict of interest: R. Di Cosola has nothing to disclose. Conflict of interest: M. Ruscica has nothing to disclose. Conflict of interest: A. Ratti has nothing to disclose. Conflict of interest: I. Rota has nothing to disclose. Conflict of interest: F. Rota has nothing to disclose. Conflict of interest: V. Bollati has nothing to disclose. Conflict of interest: S. Aliberti reports grants and personal fees from Bayer Healthcare, Aradigm Corporation, Grifols, INSMED and Chiesi, personal fees from AstraZeneca, Basilea, Zambon, Novartis, Raptor, Actavis UK Ltd and Horizon, outside the submitted work. Conflict of interest: F. Blasi reports grants and personal fees from AstraZeneca, Chiesi, GSK, Insmed and Pfizer, grants from Bayer, personal fees from Guidotti, Grifols, Menarini, Mundipharma, Novartis and Zambon, outside the submitted work.

Figures

FIGURE 1
FIGURE 1
Box plots of a) oxygen and inspiratory fraction of oxygen ratio, b) alveolar–arterial oxygen gradient, c) mean blood pressure (BP) and d) plasma potassium levels ([K+]plasma). Statistical significance was obtained through Mann–Whitney U-test comparing best status with worst status. *: p<0.001. e) Poon's analysis of PA–aO2/mean BP: n=137, slope=6.666, R2=0.757; p<0.0001. f) Poon's analysis of PA–aO2/mean BP according to [K+]plasma stratum. In (f) pale blue dots represent the group with [K+]plasma≤3.8 mmol·L−1 (n=78; slope=6.686, R2=0.774; p<0.0001) and white dots represent the group with [K+]plasma >3.8 mmol·L−1 (n=59; slope=4.491, R2=0.670; p<0.0001). PaO2: arterial oxygen tension; FIO2: inspiratory oxygen fraction; PA–aO2: alveolar–arterial oxygen tension difference.
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