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Editorial
. 2020 Jun;22(6):922-925.
doi: 10.1002/ejhf.1899. Epub 2020 Jun 20.

SARS-CoV-2-related myocarditis-like syndromes Shakespeare's question: what's in a name?

Sophie Van Linthout  1   2 , Karin Klingel  3 , Carsten Tschöpe  1   2   4
Affiliations
Editorial

SARS-CoV-2-related myocarditis-like syndromes Shakespeare's question: what's in a name?

Sophie Van Linthout et al. Eur J Heart Fail. 2020 Jun.
No abstract available

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Figures

Figure 1
Figure 1
Hypothetical cardiac inflammatory‐like pathomechanisms triggered by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). So far, different cardiac inflammatory‐like pathomechanisms triggered by SARS‐CoV‐2 have been suggested: (i) lymphocytic myocarditis induced by SARS‐CoV‐2 infection of cardiac cells (SARS‐CoV‐2‐positive lymphocytic myocarditis), (ii) cardiac SARS‐CoV‐2 presence with low‐grade inflammation, (iii) cardiac SARS‐CoV‐2 presence and global endotheliitis, (iv) lymphocytic myocarditis in the absence of cardiac infection of SARS‐CoV‐2 (SARS‐CoV‐2‐negative lymphocytic myocarditis), (v) cardiac injury elicited by a SARS‐CoV‐2 triggered interleukin (IL)‐6‐induced cytokine storm, and (vi) cardiac dysfunction due to auto‐antibodies in the absence of SARS‐CoV‐2. Differentiation of cardiac inflammatory‐like pathologies triggered by SARS‐CoV‐2 is required to allow specific treatment strategies (antiviral vs. immunosuppressive/modulating). Therefore, biomarkers are needed and model systems, including basic virology studies.
See this image and copyright information in PMC

Comment on

  • Myocardial localization of coronavirus in COVID-19 cardiogenic shock.
    Tavazzi G, Pellegrini C, Maurelli M, Belliato M, Sciutti F, Bottazzi A, Sepe PA, Resasco T, Camporotondo R, Bruno R, Baldanti F, Paolucci S, Pelenghi S, Iotti GA, Mojoli F, Arbustini E. Tavazzi G, et al. Eur J Heart Fail. 2020 May;22(5):911-915. doi: 10.1002/ejhf.1828. Epub 2020 Apr 11. Eur J Heart Fail. 2020. PMID: 32275347 Free PMC article.

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